basic FUNCTION
| converting GDP-mannose to GDP-fructose |
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GMDS controls the production of fucosylated glycans, which in turn regulates cell migration and adhesion, as well as the formation of axonal projections and synapses |
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involvement of GMDS mutation in the progression of colorectal cancer |
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is a key enzyme involved in the synthesis of GDP-fucose |
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encodes a short-chain mannose dehydrogenase enzyme involved in the regulation of hindbrain neural migration |
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short-chain mannose dehydrogenase enzyme that catalyzes the production of GDP-fucose from GDP-mannose |
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may play a role in the regulation of cell migration and axonal pathfinding |
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FOXC1, GMDS, FOXF2, and FOXQ1 may represent loci for enhancer-driven changes in gene expression that could affect the developing embryo |
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is involved in cellular fucosylation |
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amplification of GMDS and TSTA3, likely contributes to the elevated core fucose observed in hepatocellular carcinoma |