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FLASH GENE
Symbol LSAMP contributors: mct/npt - updated : 09-06-2020
HGNC name limbic system-associated membrane protein
HGNC id 6705
DNA
TYPE functioning gene
STRUCTURE 643.11 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
text structure
  • 1a and 1b promoters are expressed in brain areas involved in the processing of gustatory and olfactory information
    • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 9478 - 338 - 2003 14667507
    9 - 9485 - 361 - 2003 14667507
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainlimbic system  predominantly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral   
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    		three Ig domains and a glycosyl-phosphatidylinositol anchor
    conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • plasticity-associated IgLON family neural adhesion molecules
    • CATEGORY signaling growth factor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    text the surface of somata and proximal dendrites
    basic FUNCTION
  • mediating selective neuronal growth and axon targeting
  • neuronal surface glycoprotein found in the cortical and subcortical regions of the limbic system
  • LSAMP and NTM promote adhesion and neurite outgrowth via a homophilic mechanism, suggesting that these proteins promote the formation of specific neuronal circuits by homophilic interactions
  • function as a tumor suppressor gene in clear cell renal cell carcinoma
  • neuronal adhesive molecule, preferentially expressed in developing limbic system neuronal dendrites and somata (Must 2008)
  • might play a role in pathoaetiology of suicidal behaviour (Must 2008)
  • candidate tumor suppressor gene in osteosarcomas (Kresse 2009)
  • is a neural cell adhesion molecule involved in neurite formation and outgrowth
  • is involved in emotional and social operating systems by complex regulation of two alternative promoters
  • role for ADAM10-dependent shedding of cell surface LSAMP in promoting outgrowth from dorsal root ganglion cells (DRGs) neurons
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interplay between LSAMP and NTM in regulating tissue homeostasis: the impact of NTM on cellular proliferation was dependent on LSAMP, and LSAMP appeared to be a positive regulator of apoptosis in the presence of NTM
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   LOH    
    in osteosarcoma (Yen 2009)
    tumoral   deletion    
    in osteosarcomas (Kresse 2009)
    tumoral     --over  
    of the LSAMP and TUSC7 genes in acute myeloid leukemia
    Susceptibility
  • to late-onset coronary artery disease (CAD)
  • to ulcerative colitis (UC)
  • to schizophrenia
    • Variant & Polymorphism SNP
  • increasing the risk of late-onset coronary artery disease (CAD)(Wang 2008)
  • SNPs at ZNF649 and LSAMP, with associations of genome-wide significance for UC
  • significant allelic and haplotypic associations between LSAMP gene and schizophrenia
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS