Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ELF1 contributors: mct/ - updated : 09-05-2018
HGNC name E74-like factor 1 (ets domain transcription factor)
HGNC id 3316
DNA
TYPE functioning gene
STRUCTURE 87.45 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 3760 - 619 - 1998 9524226
8 - 3543 - 595 - 1998 9524226
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node   highly
Respiratoryrespiratory tracttrachea  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
cell lineage lymphoid and myeloid cells
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal A transactivation domain
  • a central AT hook domain
  • a C terminal ETS DNA binding protein
  • HOMOLOGY
    interspecies homolog to C.elegans c30b5.1
    Homologene
    FAMILY
  • ETS family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • involved in the transcriptional regulation of several hematopoietic cell genes
  • regulating vascular-specific gene expression during blood vessel development
  • transcriptional regulator of TEK
  • required for the T-cell-receptor-mediated trans activation of HIV-2 gene expression
  • involved in transcriptional activation of PYGO2
  • involved in T cell development and function
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to both Ets binding sites (EBS1,EBS2) of IL2 enhancer
    RNA
    small molecule
    protein
  • binding to RB1 in resting normal T cells
  • in the nucleus, binds to the promoter of the TCR zeta gene and promotes its transcription in Jurkat and fresh T cells
  • interacting with GATA3
  • interaction with LAT (overexpression of ELF1 augments LAT promoter activity)
  • an important positive regulator of MEIS1 expression
  • FLI1, ELF1, and GABPA regulate PF4 gene expression through the -51 ETS site in megakaryocytes and implicate the differentiation stage-specific regulation of PF4 gene expression by multiple ETS factors
  • ELF1 binds an important duplicated GGAA cis-acting element at the OAS1 promoter and in cooperation with RB1 and SP1 recruitment contributes to regulation in response to IFN stimulation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    with decreased TCR zeta chain gene expression in patients with systemic lupus erythematosus
    Susceptibility to systemic lupus erythematosus
    Variant & Polymorphism other polymorphisms increasing the risk of systemic lupus erythematosus
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS