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FLASH GENE
Symbol FUT8 contributors: mct - updated : 20-10-2015
HGNC name fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
HGNC id 4019
DNA
TYPE functioning gene
STRUCTURE 333.53 kb     11 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 5179 - 575 - 1999 10343104
V1, or B4
- - 3291 - 575 - 1999 10343104
10 - 5081 - 575 - 1999 10343104
10 - 4749 - 412 - 1999 10343104
- - 1396 - 169 - 1999 10343104
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
Nervousbrain   highly Homo sapiens
Reproductivefemale systembreastmammary gland highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentral    Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,Golgi
basic FUNCTION
  • involved in the biosynthesis of asparagine-linked glycoprotein oligosaccharides
  • relationship between FUT8 and the regulation of EGF receptor (EGFR)-trypsin-PAR-2 pathway in controlling cell growth
  • transfers fucose to the innermost N-acetylglucosamine unit of N-glycan chains
  • catalyzes the transfer of a fucose residue to N-linked oligosaccharides on glycoproteins via an alpha-1,6 linkage, leading to core fucosylation in mammals
  • is a novel factor for hemoglobin production and core fucosylation plays an important role in erythroid differentiation
  • plays potentially a dual role in TGFB1/activin-mediated signaling
  • Golgi-localized alpha1,6 fucosyltransferase that is essential for transferring the monosaccharide fucose into N-linked glycoproteins, a process known as “core fucosylation"
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • FUT4-, FUT6- or FUT8-mediated multidrug resistance (MDR) in hepatocellular carcinoma is associated with the activation of the PI3K/Akt pathway and the expression of ABCC1
  • cell & other
    REGULATION
    Other can be regulated also through miRNA-mediated mechanisms
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in thyroid papillary carcinoma directly linked to tumor size and lymph node metastasis
    tumoral     --over  
    in several malignant cancers including liver, ovarian, thyroid, and colorectal cancers
    tumoral     --over  
    in nonsmall cell lung cancer (NSCLC) and correlates with tumor metastasis, disease recurrence, and poor survival
    tumoral     --other  
    altered expression of fucosylation pathway gene(FUT8), correlated with poor survival in patients with non&8209;small cell lung cancer (NSCLC)
    Susceptibility to pulmonary emphysema (PE)
    Variant & Polymorphism SNP
  • FUT8 gene Thr267Lys polymorphism is associated with human PE, and the Lys allele is the risk
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Fut8-deficient (Fut8-/-) mice exhibit growth retardation, earlier postnatal death, and emphysema-like phenotype
  • Fut8-deficient mice develop pathological and physiological phenotypes resembling pulmonary emphysema (PE)