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FLASH GENE
Symbol LAD1 contributors: npt/ - updated : 02-11-2004
HGNC name ladinin 1
HGNC id 6472
DNA
TYPE functioning gene
STRUCTURE 18.70 kb     10 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 2869 57 517 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticthymus    
digestiveesophagus    
Digestiveintestine    
 liver    
Endocrinepancreas    
Nervousbrain    
Reproductivemale systemprostate   
Respiratorylung    
Skin/Tegumentskin    
Urinarybladder    
 kidneytubule   
 kidneynephron   
 ureter    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialabsorptive excretorydigestive epithelium  
Epithelialbarrier/lininguroepithelium  
Epithelialsecretoryglandularexocrine 
Epithelialsecretoryglandularendocrine 
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Skin/Tegumentkeratinocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a secretory signal sequence
  • several putative glycosylation sites
  • six SEK motifs which may participate in macromolecular interactions (Motoki 1997)
  • HOMOLOGY
    interspecies homolog to Mus cookii ladinin 1
    homolog to C.elegans F55F8.4
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION extracellular
    text
  • extracellular matrix
  • localized to anchoring filaments underlying hemidesmosomes of the lamina lucida of the epidermal basement membrane
  • basic FUNCTION
  • contributing to the stability of the association of the epithelial layers with the underlying mesenchyme
  • maintaining dermal-epidermal cohesion
  • autoantigen associated with linear IgA disease (Motoki 1997)
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of the basement membranes
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS