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FLASH GENE
Symbol SLC22A2 contributors: mct/pgu - updated : 02-09-2013
HGNC name solute carrier family 22 (organic cation transporter), member 2
HGNC id 10966
DNA
TYPE functioning gene
STRUCTURE 42.17 kb     11 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
Binding site
text structure
  • promoter with binding sites for specific transcription factors
  • regulatory polymorphism affecting the promoter activity in kidney
  • MAPPING cloned Y linked   status provisional
    Physical map
    VIL2 6q25-q26 villin 2 (ezrin) LOC389439 6 LOC389439 LOC202459 6q25.3 similar to RIKEN cDNA 2310008M10 LOC389440 6 LOC389440 LOC346064 6q25.3 similar to SNARE protein Ykt6; YKT6, S. cerevisiae, homolog of RSHL2 6q25.3 radial spokehead-like 2 TAGAP 6q25.3 T-cell activation GTPase activating protein LOC389441 6 LOC389441 LOC389442 6 LOC389442 LOC389443 6 LOC389443 LOC389444 6 similar to frazzled CG8581-PA FNDC1 6q25 fibronectin type III domain containing 1 LOC389445 6 similar to 60S ribosomal protein L21 SOD2 6q25.2 superoxide dismutase 2, mitochondrial WTAP 6q25-q27 Wilms tumor 1 associated protein ACAT2 6q25.3-q26 acetyl-Coenzyme A acetyltransferase 2 (acetoacetyl Coenzyme A thiolase) TCP1 6q25.1-q25.2 t-complex 1 MRPL18 6q25.3 mitochondrial ribosomal protein L18 PNLDC1 6q25.3 poly(A)-specific ribonuclease (PARN)-like domain containing 1 MAS1 6q25.3-q26 MAS1 oncogene IGF2R 6q26-q27 insulin-like growth factor 2 receptor SLC22A1 6q27 solute carrier family 22 (organic cation transporter), member 1 SLC22A2 6q26-q27 solute carrier family 22 (organic cation transporter), member 2 SLC22A3 6q26-q27 solute carrier family 22 (extraneuronal monoamine transporter), member 3 APOAL 6q26-q27 apolipoprotein A-like LPA 6q26-q27 lipoprotein, Lp(a) PLG 6q26 plasminogen LOC389446 6 similar to apolipoprotein(a) (EC 3.4.21.-) - rhesus macaque (fragment) LOC389447 6 LOC389447 MAP3K4 6q25.3 mitogen-activated protein kinase kinase kinase 4 AGPAT4 6q25.3 1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta) C6orf59 6q25.3 chromosome 6 open reading frame 59 PARK2 6q25.2-q27 Parkinson disease (autosomal recessive, juvenile) 2, parkin
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 splicing 2512 62.6 555 kidney 2002 12089365
    also called OCT2-B
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainlimbic systemhippocampus   Homo sapiens
     spinal cordanterior horn    Homo sapiens
    Urinarykidney   specific Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialabsorptive excretoryrenal tubular epithelium   Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervouscholinergic neuron Homo sapiens
    Nervousneuron Homo sapiens
    Urinaryepithelial cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES acid
    STRUCTURE
    motifs/domains
  • twelve transmembrane domains (12TM),with cytoplasmic N and C termini
  • one nucleotide (ATP/GTP) binding site motif
  • cysteines of the extracellular loop are crucial for trafficking of human organic cation transporter 2 to the plasma membrane and are involved in oligomerization
  • HOMOLOGY
    Homologene
    FAMILY
  • major facilitator superfamily
  • organic cation transporter family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • polyspecific transporter of organic cations, sodium independent, may be mediating the first step in cation reabsorption
  • non-neuronal monoamine transporters that play a key role in the clearance of monoamines from extracellular compartments
  • plays a crucial role in the renal secretion of organic cations
  • drug transporter that is a critical determinant in the uptake and cytotoxicity of various platinum compounds, particularly oxaliplatin
  • SLC47A1 and SLC22A2 are transport systems that may be of importance for the cellular disposition of agmatine and putrescin
  • involved in the transport of endogenous and exogenous organic cations mainly in cells of the kidney and the brain
  • important postsynaptic determinant of aminergic tonus and mood-related behaviors (PMIS: 21769100)
  • involved in transport of many endogenous and exogenous organic cations, mainly in kidney and brain cells
  • plays a decisive role in the renal secretion of creatinine
  • could work as a low-affinity and high-capacity choline transporter at presynaptic terminals in cholinergic neurons in a firing-dependent manner
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS facilitated diffusion transport
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • kidney-specific expression of SLC22A2 is regulated by methylation of the proximal promoter region, interfering with the transactivation by USF1
  • coordinate function of SLC47A1 with SLC22A2 likely contributes to the vectorial renal elimination of organic cationic drugs
  • LAPTM4A is an interaction partner of SLC22A2 (LAPTM4A regulates the function of SLC22A2 by influencing its trafficking to/from the cell membrane and processing it via the intracellular sorting machinery)
  • DDAH1 and L-arginine are substrates of human SLC7A2, SLC22A2, SLC47A1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    psychiatry  
    potential pharmacological target for mood disorders therapy
    ANIMAL & CELL MODELS