Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
tumoral
|  
|  
|  
| loss of function
|
by hypermethylation in bladder cancer |
tumoral
|  
| deletion
|  
|  
|
in bladder carcinoma, ovarian cancer, squamous cell carcinoma of esophagus, large B cell lymphoma |
tumoral
|  
| LOH
|  
|  
|
in hepatocellular carcinoma, urinary-bladder cancer, breast cancer, tuberous sclerosis, hamartoma |
tumoral
|  
| amplification
|  
|  
|
in large B cell lymphoma and in laryngeal and pharyngeal squamous cell carcinoma |
tumoral
| somatic mutation
|  
|  
|  
|
in nevoid basal cell carcinoma |
tumoral
|  
|  
|  
| loss of function
|
in non-small cell lung cancer by hypermethylation of the promoter or homozygous deletion |
tumoral
|  
| LOH
|  
|  
|
and hypermethylation of the promoter frequent and possibly early events in oral malignant development |
tumoral
|  
|  
| --low
|  
|
by hypermethylation of the promoter region is a frequent event during the development of lymphoproliferative malignancies |