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FLASH GENE
Symbol DHX15 contributors: mct/npt - updated : 30-10-2017
HGNC name DEAH (Asp-Glu-Ala-His) box polypeptide 15
HGNC id 2738
DNA
TYPE functioning gene
STRUCTURE 57.10 kb     14 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
SLIT2 4p15.2 slit homolog 2 (Drosophila) MGC29898 4p15.32 hypothetical protein MGC29898 KCNIP4 4p15.32 Kv channel interacting protein 4 FLJ30194 4p15.32 hypothetical protein FLJ30194 GPR125 4p15.32-p15.31 G protein-coupled receptor 125 GBA3 4p15.31 glucosidase, beta, acid 3 (cytosolic) PPARGC1 4p15.1 peroxisome proliferative activated receptor, gamma, coactivator 1 DHX15 4p15.3 DEAH (Asp-Glu-Ala-His) box polypeptide 15 LOC391640 4 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP) SOD3 4p16.3-q21 superoxide dismutase 3, extracellular DKFZp761B107 4p15.31 hypothetical protein DKFZp761B107 LGI2 4p15.31 leucine-rich repeat LGI family, member 2 SLA/LP 4p15.31 soluble liver antigen/liver pancreas antigen PI4K2B 4p15.31 phosphatidylinositol 4-kinase type-II beta ANAPC4 4p15.31 anaphase-promoting complex subunit 4 LOC345348 4p15.31 similar to D-myo-inositol-3-phosphate synthase LOC391641 4 similar to chloroquine resistance marker protein SLC34A2 4p15.3-p15.1 solute carrier family 34 (sodium phosphate), member 2 KIAA0746 4p15.2 solute carrier family 34 (sodium phosphate), member 2 LOC389203 4 hypothetical gene supported by BC032431 RBPSUH 9p13-p12 recombining binding protein suppressor of hairless (Drosophila) CCKAR 4p15.2-p15.1 cholecystokinin A receptor FLJ11082 4p15.31 hypothetical protein FLJ11082 STIM2 4p15.2 stromal interaction molecule 2 LOC389204 4 LOC389204 MRPL51P1 4p15.2 LOC389204 LOC391642 4 similar to Immunoglobulin-binding protein 1 (CD79a-binding protein 1) (B cell signal transduction molecule alpha 4) (Alpha 4 protein) LOC285509 4p15.2 hypothetical LOC285509 LOC391643 4 similar to mesoderm specific transcript isoform a; paternally expressed gene 1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 3019 - 795 - 2017 28115624
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouth   highly
Hearing/Equilibriumear   highly
Lymphoid/Immunethymus   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • DEAD/H box (Asp-Glu-Ala-His)
  • N terminal RGD motif,an Arg-Asp repeat (RD) RNA binding motif
  • N terminal helicase domain, and N-terminal domain containing a DEXDc motif bound the C terminus of MAVS
  • C terminal helicase associated domain
  • HOMOLOGY
    interspecies ortholog to yeast Prp43
    Homologene
    FAMILY
  • DEAD box helicase family
  • DEAH subfamily
  • DDX15/PRP43 sub-subfamily
  • CATEGORY enzyme , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • RNA helicase with RNA dependent ATPase activity
  • DEAH-box RNA-dependent ATPase that catalyzes the release of excised lariat intron from the mRNA spliceosome
  • putative ATP-dependent RNA helicase implicated in pre-mRNA splicing
  • in cooperation with TFIP11 mediates the transition from the intron large complex to the intron small complex, leading to efficient debranching and turnover of excised introns (Yoshimoto 2009)
  • DHX15 activates NFKB1 and MAPK signaling downstream of MAVS during antiviral responses
  • is a new RNA virus sensor mediated by MAVS to activate the immune responses to RNA
  • CELLULAR PROCESS nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    text preRNA splicing
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with SSB (may be colocalized in the nucleoli)
  • interacting with TFIP11 (protein component of the spliceosome complex that promotes the release of the lariat-intron during late-stage splicing through a direct recruitment and interaction with DHX15) (Tannukit 2009)
  • DHX15 and PRPF19, two spliceosome components, are novel RBM5-interacting partner
  • DHX15 physically interacted with MAVS and mediated the MAVS-dependent activation of the NFKB1 and MAPK pathways
  • NLRP6 functions with DHX15 as a viral RNA sensor to induce IFN-stimulated genes (ISGs), and this effect is especially important in the intestinal tract
  • NKRF mediates the recruitment of the exonuclease XRN2 and activation of the RNA helicase DHX15 in human ribosome biogenesis
  • DHX15 regulates AR activity by modulating E3 ligase SIAH2-mediated AR ubiquitination independent of its ATPase activity
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS