motifs/domains
| N terminus interacts directly with variant-specific residues in the H3F3A, and H3F3B core |
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two predicted paired amphipathic helices (PAH1 and PAH2) |
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a glutamic acid-rich domain |
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two separate nuclear localizing domains, NLS1, NLS2 |
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a Ser/Pro/Thr (SPT)-rich domain |
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a coiled-coil (CC), an acidic domain (acidic) |
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and an rtt106-like domain (rtt106) |
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N- and/or C-terminal SUMO-interacting motifs (SIM-N and SIM-C) |
basic FUNCTION
| enhancing Fas-mediated apoptosis through the JNK signal transduction pathway |
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potential regulator of FAS-induced apoptosis from nuclear oncogenic domains POD in which it colocalizes with PML |
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mediating its pro and antiapoptotic function in part or entirely through its activating effect on HSF1 and the stress protein response |
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functioning as a transcriptional regulator |
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involved in the repression of transcriptional activation of the MMP1 and BCL2 genes |
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multi-functional protein modulating both apoptosis and transcription |
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promotes Fas-mediated cell death through activation of apoptosis signal-regulating kinase 1, leading to the activation of the MAPKs JNK and p38 |
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critical regulator of T-lymphocyte homeostasis by decreasing TCR-induced cell proliferation and by promoting Fas-mediated cell death |
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plays a major role in several important signaling pathways including transcription and cell death |
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inhibits stress-induced apoptosis in cardiac myocytes |
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inhibits E2A function, and it recruits histone deacetylase activity to E2A-dependent promoters |
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functions as a positive coregulator in modulating the beta-catenin/TCF4-dependent transcriptional potential via TCF4 interaction |
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functions as a bona fide histone chaperone involved in the replication-independent deposition of H3F3A |
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required for assembly of H3F3A nucleosomes onto pericentric DNA repeats |
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with ATRX are required for H3F3A deposition onto pericentric DNA repeats outside the S phase, and the DAXX/ATRX complex uses H3F3A to modulate the transcription from these repeats |
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functions as an H3F3-specific chaperone and facilitates the deposition of H3F3a and H3F3B at heterochromatin loci in the context of the ATRX–DAXX complex |
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essential scaffold protein with key roles in diverse cellular processes spanning transcription to apoptosis and mitosis |
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FTH1 and DAXX are able to participate in apoptosis pathway through JNK signal molecule and FTH1 can inhibit this pathway |
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functioned as a signal transducer linking cAMP-stimulated HIPK3 activity with JNK/JUN phosphorylation and NR5A1-dependent CYP11A1 transcription for steroid synthesis |
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is essential for NR5A1-dependent transcription of CYP11A1 |
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histone chaperone specific to the evolutionarily conserved histone variant H3F3A |