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FLASH GENE
Symbol MUTYH contributors: mct/npt - updated : 11-06-2010
HGNC name mutY homolog (E. coli)
HGNC id 7527
DNA
TYPE functioning gene
STRUCTURE 11.23 kb     16 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
16 - 1905 - 535 - Slupska (1996)
16 - 1794 - 522 - Slupska (1996)
16 - 1791 - 521 - Slupska (1996)
16 - 1710 - 521 - Slupska (1996)
16 - 1945 - 549 - Slupska (1996)
16 - 1936 - 546 - Slupska (1996)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivestomach   highly
Lymphoid/Immunelymph node    
 thymus   highly
Reproductivefemale systemuteruscervix  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • Mut T-like domain
  • iron sulphur binding domain
  • HOMOLOGY
    interspecies homolog to E.coli mutY
    Homologene
    FAMILY
  • nth/mutY family
  • CATEGORY enzyme , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • involved in the repair of oxidative DNA damage
  • CELLULAR PROCESS nucleotide, repair
    PHYSIOLOGICAL PROCESS
    text DNA repair/endonuclease
    PATHWAY
    metabolism
    signaling
    chromosome instability pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with the mismatch repair protein hMSH6
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MAP
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral germinal mutation      
    in attenuated familial adenomatous polyposis
    Susceptibility
  • to colorectal cancer
  • to attenuated familial adenomatous polyposis
  • Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS