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FLASH GENE
Symbol CIRBP contributors: mct - updated : 28-01-2015
HGNC name cold inducible RNA binding protein
HGNC id 1982
DNA
TYPE functioning gene
STRUCTURE 5.54 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned   linked   status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 1397 18 172 - -
- - 1170 - 168 - -
- - 1790 - 297 - -
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunespleen   highly
 thymus   highly
Nervousbrain   highly
 nerve   highly
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivegerm cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal RNA Recognition Motif (RRM)
  • C-terminal domain containing several RGG motifs
  • HOMOLOGY
    interspecies homolog to murine Cirp
    Homologene
    FAMILY
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,granule
    intracellular,nucleus,nucleoplasm
    text
  • methylation of arginine residues in the RGG domain is necessary for CIRBP to exit the nucleus to be further recruited into stress granules (SGs)
  • basic FUNCTION
  • but likely excluded as the responsible gene
  • may be playing an essential role in cold-induced suppression of cell proliferation
  • may participate in the cell cycle regulation of normal endometrium and the loss of its expression may be involved in endometrial carcinogenesis
  • expression of CIRBP accelerates the G0/G1-to-S phase transition without affecting apoptosis
  • RBM3 and CIRBP are two established cold-shock proteins
  • CIRBP fine-tunes the cell-cycle progression of undifferentiated spermatogonia as well as fibroblasts and cancer cells by interacting with and suppressing kinase activity of DYRK1B to modulate the protein levels of CDKN1B and CCND1
  • RNA-binding protein that is expressed in normal testis and down-regulated after heat stress
  • CIRBP and RBM3, are important regulators for the temperature entrained circadian gene expression
  • extracellular CIRBP is a detrimental factor in stimulating inflammation to cause neuronal damage in cerebral ischemia
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • CIRBP forms a complex together with DYRK1B and CCND1
  • INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • mild hypothermia protects cells from TNF-induced apoptosis, at least partly, via induction of CIRBP, and CIRBP protects cells by activating the ERK pathway
  • CIRBP functions to fine-tune the proliferation of undifferentiated spermatogonia by interacting with DYRK1B
  • NFKB1-dependent role for CIRBP in regulating IL1B
  • CIRBP and RBM3 regulated the circadian gene expression by controlling alternative polyadenylation (APA)
  • cell & other
    REGULATION
    induced by stresses such as UV irradiation and hypoxia
    inhibited by the respiratory chain inhibitors NaN(3) and cyanide in a dose-dependent fashion
    repressed by TNF and TGFB1 that impair the expression of CIRBP in fibroblasts and neuronal cells
    Other cold inducible
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    may reduce the damage caused by testicular torsion/detorsion, possibly by preventing germ cell oxidative stress and apoptosis
    constitutional     --over  
    may reduce testicular damage induced by cryptorchidism by down-regulating the levels of TP53 and FAS
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Cirp-deficient mice have reduced numbers of undifferentiated spermatogonia, although the total numbers of testicular germ cells and fertility were not significantly decreased