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FLASH GENE
Symbol CAPN5 contributors: mct - updated : 11-07-2017
HGNC name calpain 5
HGNC id 1482
DNA
TYPE functioning gene
STRUCTURE 59.21 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Map cen - D11S913 - D11S916 - CAPN5 - D11S901 - D11S1354 - qter
Authors Mugita (97)
Physical map
RPS3 11q13.3-q13.5 ribosomal protein S3 FLJ33790 11q13.3 hypothetical protein FLJ33790 PP1665 11q13.3 hypothetical protein PP1665 SERPINH1 11q13.5 serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) MAP6 6p12-p11 microtubule-associated protein 6 MGAT2 14q21 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase DGAT2 11q13.3 diacylglycerol O-acyltransferase homolog 2 (mouse) UVRAG 11q13 UV radiation resistance associated gene WNT11 11q13.5 wingless-type MMTV integration site family, member 11 PRKRIR 11q13.5 protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) LOC387790 11 LOC387790 C11orf30 11q13.5 chromosome 11 open reading frame 30 GARP 11q13.5-q14 glycoprotein A repetitions predominant LOC390226 11 similar to Olfactory guanylyl cyclase GC-D precursor (Guanylate cyclase, olfactory) E2IG4 11q13.3 hypothetical protein, estradiol-induced PHCA 11q13.4 phytoceramidase, alkaline IMAGE:4907098 11q13.4 beta-1,3-N-acetylglucosaminyltransferase protein CAPN5 11q14 calpain 5 OMP 11q13 olfactory marker protein MYO7A 11q13.5 myosin VIIA (Usher syndrome 1B (autosomal recessive, severe)) LOC220032 11q13.4 GDPD domain containing protein LOC387791 11 similar to Mitochondrial import receptor subunit TOM20 homolog (Mitochondrial 20 kDa outer membrane protein) (Outer mitochondrial membrane receptor Tom20) PAK1 11q13.5-q14.1 p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast) LOC387792 11 LOC387792 AQP11 11q13.4 aquaporin 11 CLNS1A 11q13.5-q14.1 chloride channel, nucleotide-sensitive, 1A HBXAP 11q13.4-q14.1 hepatitis B virus x associated protein PTD015 11q13.4 PTD015 protein MGC16733 11q13.4 hypothetical gene MGC16733 similar to CG12113 KCTD14 11q13.4 potassium channel tetramerisation domain containing 14 THRSP 11q13.5 thyroid hormone responsive (SPOT14 homolog, rat) NDUFC2 11q12.1-q13.14 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa ALG8 11pter-p15.5 asparagine-linked glycosylation 8 homolog (yeast, alpha-1,3-glucosyltransferase) LOC387793 11 hypothetical gene supported by BC062331 LOC387794 11 similar to ubiquitin specific protease 38; HP43.8KD protein USP35 11q13.4 ubiquitin specific protease 35 GAB2 11q13.4-q13.5 GRB2-associated binding protein 2 FLJ23441 11q13.4 hypothetical protein FLJ23441 ODZ4 11q13.4 odd Oz/ten-m homolog 4
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 4393 - 640 - 2016 27152965
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
 intestinelarge intestinecolon specific
Endocrineneuroendocrinepituitary  highly
Nervousbraindiencephalonhypothalamus highly Homo sapiens
 brainhindbraincerebellum highly
Visualeyeretina    Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentral    Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Olfactoryolfactory receptor
Visualcone photoreceptor Homo sapiens
Visualrod photoreceptor Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal regulatory domain processed after activation, and an N-terminal monopartite NLS
  • protein domain (II), linker (III)
  • C terminal T domain (not containing a calmodulin-like EF hand motifs), and a unique bipartite NLS closer to the C terminus; C-terminal NLS contains a SUMO-interacting motif that contributes to nuclear localization, and mutation or deletion of both NLS renders CAPN5 exclusively cytosolic
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to C.elegans sex determination gene tra3
    Homologene
    FAMILY
  • papain superfamily, nCL-3 type
  • olfactory marker protein family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • calcium dependent neutral cysteine proteinase (non lysosomal)
  • may act as a modulator of the olfactory signal- transduction cascade
  • calcium-activated cysteine protease
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text signal transduction
    PATHWAY
    metabolism
    signaling signal transduction
    a component heterodimerezing with a small subunit
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    calcium Ca2+
    protein
  • interacts with BEX1 and BEX2
  • CAPN5 is a target of HOXA10 transcriptional regulation in endometrial cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in both stromal and glandular cells from women with endometriosis compared with that of fertile controls
    Susceptibility to polycystic ovary syndrome
    Variant & Polymorphism other GGCA and GGTG were overrepresented in polycystic ovary syndrome patients
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS