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FLASH GENE
Symbol CEP350 contributors: mct - updated : 26-06-2018
HGNC name centrosomal protein 350kDa
HGNC id 24238
DNA
TYPE functioning gene
STRUCTURE 160.11 kb     38 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13473 - 38 - 3117 - 2006 16314388
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
one CAP-Gly domain
HOMOLOGY
interspecies homolog to murine Cep350
intraspecies homolog to restin
Homologene
FAMILY
CATEGORY structural protein
SUBCELLULAR LOCALIZATION     plasma membrane,junction,adherens
    intracellular
intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
intracellular,nucleus
text
  • centrosomal microtubule (MT)-binding protein CAP350 localises at adherens junctions in epithelial cells
  • CEP350 is not only present at the centrosome, but is also present as numerous dots in the pericentrosomal area, and bound preferentially to microtubules in the pericentrosomal area
  • basic FUNCTION
  • anchoring microtubules at the centrosome
  • implicated in the regulation of a class of nuclear hormone receptors in the nucleus
  • CEP350 specifically stabilises Golgi-associated microtubules and in this way participates in the maintenance of a continuous pericentrosomal Golgi ribbon
  • CEP350 may act as an adaptor between adherens junctions and microtubules, thus regulating epithelial differentiation and contributing to the definition of cell architecture
  • role for the CEP19, FGFR1OP and CEP350 module in ciliogenesis and the possible effect of disrupting their functions in ciliopathies
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CFAP157 interacts with tubulin and the centrosomal protein CEP350
  • CEP19 is recruited to the ciliary base by the centriolar CEP350/FOP complex and then specifically captures GTP-bound RABL2B, which is activated via its intrinsic nucleotide exchange
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS