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FLASH GENE
Symbol PLCH2 contributors: - updated : 22-11-2006
HGNC name phospholipase C, eta 2
HGNC id 29037
DNA
TYPE functioning gene
STRUCTURE 29.21 kb     22 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
22 - 4837 - 1416 - Stewart (2005)
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineneuroendocrinepituitary   
 pancreas    
Nervousnervecranial nerve   
Respiratorylung    
Urinarykidney    
Visualeyeretina   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a C2 domain
  • an EF-hand domain
  • a PI-PLC X-box domain
  • a PI-PLC Y-box domain
  • HOMOLOGY
    intraspecies homolog to chain precursor of collagen IV alpha 4
    Homologene
    FAMILY
  • phosphoinositide-specific phospholipase C (PLC) superfamily
  • the PLC-eta family
  • CATEGORY enzyme , structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • likely involved in signal transduction pathways (Stewart 2005)
  • phosphoinositide phospholipase C activity activated by G protein beta-1-gamma-2 dimers (Zhou 2005)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling signal transduction
    intracellular signaling cascade
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS