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FLASH GENE
Symbol CDC5L contributors: mct/pgu - updated : 02-06-2015
HGNC name CDC5 cell division cycle 5-like (S. pombe)
HGNC id 1743
DNA
TYPE functioning gene
STRUCTURE 59.48 kb     16 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map pter - D6S271 /D6S451 /D6S282 - [ ] - D6S459 - cen
Text [ ]:breakpoint in CDC5L
Physical map
VEGF 6p12 vascular endothelial growth factor LOC389392 6 LOC389392 MGC45491 6p21.1 hypothetical protein MGC45491 LOC391921 6 similar to 60S ribosomal protein L29 (Cell surface heparin binding protein HIP) MRPL14 6p21.3 mitochondrial ribosomal protein L14 C6orf110 6p21.1 chromosome 6 open reading frame 110 CAPN11 6p12 calpain 11 LOC389393 6 LOC389393 SLC29A1 6p21.2-p21.1 solute carrier family 29 (nucleoside transporters), member 1 HSPCB 6p12 heat shock 90kDa protein 1, beta SLC35B2 6p12.1-p11.2 solute carrier family 35, member B2 NFKBIE 6p21.1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon LOC391922 6 similar to hypothetical protein MGC33486 MGC33600 6p21.1 hypothetical protein MGC33600 AARSL 6p21.1 alanyl-tRNA synthetase like SPATS1 6p21.1 spermatogenesis associated, serine-rich 1 CDC5L 6p21 CDC5 cell division cycle 5-like (S. pombe) SUPT3H 6p21.3-p21.1 suppressor of Ty 3 homolog (S. cerevisiae)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
16 - 3012 - 802 - 2008 18583928
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text fetal tissue
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two HTH myb-type DNA binding domains
  • conjugated PhosphoP
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Cdc5l (98.0pc)
    homolog to rattus Cdc5l (97.9pc)
    intraspecies homolog to CDC5-like-sequence
    homolog to Myb
    Homologene
    FAMILY
  • CEF1 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text may shuttle between cytoplasm and nucleus
    basic FUNCTION
  • acts as a positive regulator of cell cycle G2/M progression
  • may act as a transcriptional activator
  • seems to be involved in the second catalytic step of pre-mRNA splicing
  • a cell cycle regulator important for the G2-M transition, that possesses potential oncogenic activity in osteosarcoma
  • involved in the cellular response to DNA damage
  • is required for the activation of downstream effectors or mediators of ATR checkpoint function such as CHEK1, RAD17 and FANCD2
  • spliceosomal subcomplex that also plays a role in DNA repair
  • CELLULAR PROCESS cell cycle, checkpoint
    cell cycle, progression
    nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the spliceosome complex (CDC5l, PLRG1, SPF27, CCAP1, CCAP3, CCAP6)
  • INTERACTION
    DNA binding to adeno-pre-mRNA in an ATP-stimulated manner
    RNA
    small molecule
    protein
  • interaction between CDC5L and PLRG1 essential for pre-mRNA splicing
  • interacting with DAPK3
  • interacting with ATR
  • CTNNBL1 associates with the PRPF19 complex of the spliceosome, interacting with its CDC5L component
  • BCAS2 directly interacts with each component of the PRPF19/CDC5L complex core
  • interaction between HNRPM and the spliceosome proteins cell division cycle 5-like (CDC5L) and pleiotropic regulator 1 (PLRG1) that was inhibited during the heat-shock stress response
  • cell & other
    REGULATION
    Other phosphorylation of CDC5L is required for CDC5L-mediated pre-mRNA splicing
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   translocation    
    translocation t(6;19) (p21;q13),in multicystic renal dysplasia (see also PUJO)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • may be an oncogene for the 6p12-p21 amplicon found in osteosarcoma
  • Marker
    Therapy target
    ANIMAL & CELL MODELS