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Symbol ATP5MC2 contributors: mct - updated : 21-05-2019
HGNC name ATP synthase membrane subunit c locus 2
HGNC id 842
DNA
TYPE functioning gene
STRUCTURE 12.39 kb     5 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 1178 - 157 - 2017 28289229
5 - 898 - 198 - 2017 28289229
5 - 2131 - 141 - 2017 28289229
6 - 730 - 141 - 2017 28289229
6 - 873 - 141 - 2017 28289229
5 - 690 - 141 - 2017 28289229
5 - 634 - 103 - 2017 28289229
6 - 750 - 143 - 2017 28289229
5 - 626 - 139 - 2017 28289229
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
HOMOLOGY
interspecies homolog to C.elegans r10e11.2
Homologene
FAMILY
  • ATPase c chain family
  • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • ATP synthesis, catalytic unit
  • intrinsic membrane component of ATP synthase
  • ATP5MC1, ATP5MC2, ATP5MC3 are nonredundant, because they differ functionally by their targeting peptides, which, in addition to mediating mitochondrial protein import, play a yet undiscovered role in respiratory chain maintenance
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport
    text protein
    PATHWAY
    metabolism energetic
    signaling
    energy pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       loss of function
    by promoter region methylation in primary renal cell carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS