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FLASH GENE
Symbol ORC5 contributors: mct/ - updated : 15-01-2004
HGNC name origin recognition complex, subunit 5
HGNC id 8491
DNA
TYPE functioning gene
STRUCTURE 81.68 kb     14 Exon(s)
MAPPING cloned Y linked N status confirmed
regionally located in a segment commonly deleted in myeloid malignancies
RNA
TRANSCRIPTS type messenger
text alternative splicing
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 1310 - 324 - -
also called ORC5LT
14 - 1968 - 435 - -
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen   highly
Digestiveintestinelarge intestinecolon highly
Reproductivefemale systemovary  highly
 male systemtestis  highly
 male systemprostate  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialabsorptive excretorydigestive epithelium  
Epithelialbarrier/lininguroepithelium  
Epithelialsecretoryglandularexocrine 
Lymphoid    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer , complex
HOMOLOGY
interspecies homolog to yeast (origin of replication recognition complex,subunit ) ORC5-like
homolog to murine Orc5
homolog to C.elegans zc168.3
Homologene
FAMILY
  • ORC family
  • CATEGORY regulatory , DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • regulator of the initiation of DNA replication and transcription (silencing)
  • implicated in many cellular activities, including DNA replication, transcriptional control, heterochromatin assembly, centromere and telomere function
  • CELLULAR PROCESS nucleotide, replication
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • one of the six subunits of the origin recognition complex
  • INTERACTION
    DNA binding to autonomously replication sequence (ARS) consensus sequence (ACS)
    RNA
    small molecule
    protein
  • ORC2, ORC3, ORC4
  • interaction of CDT1 with ORCs is involved in the formation of the prereplicative complex, rather than in regulation of the activity of ORCs
  • connection between ORCs and chromatin structure via the Set1 complex
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene candidate tumor suppressor gene for myeloid disorders
    Marker
    Therapy target
    ANIMAL & CELL MODELS