basic FUNCTION
| involved in protein-protein interaction |
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regulating signal-dependent transcription |
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having a structural role in the remodelling of acetylated chromatin |
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required maternally for proper expression of other homeotic genes involved in pattern formation, such as UBX |
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could also have a new biological role, specific to germ cells, which could be performed by its nonconserved domains |
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implicated in the marked chromatin remodelling that follows histone hyperacetylation during spermiogenesis, the stage of spermatogenesis in which post-meiotic germ cells mature into fully differentiated sperm |
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BET family members have been recognized as essential genes for the replication of viruses and in mediating inflammatory responses |
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BET family proteins recognize acetylated chromatin through their two bromodomains, acting as transcriptional activators or tethering viral genomes to the mitotic chromosomes of their host |
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along with modulating transcription, BRDT modulates likely gene expression as part of the splicing machinery, and these modulations alter 3'-UTR processing in round spermatid |
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BRD2, BRD3, BRD4, and BRDT are transcriptional regulators required for efficient expression of several growth promoting and antiapoptotic genes as well as for cell-cycle progression |
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is essential for the normal progression of spermatogenesis as mutations in the BRDT gene result in complete male sterility |
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is an essential regulator of chromatin organization and reprograming during prophase I of meiosis |
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also controls the global chromatin organization and histone modifications of the chromatin attached to the synaptonemal complex |