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FLASH GENE

Symbol

HSPB2

contributors: mct - updated : 12-11-2016

HGNC name	heat shock 27kDa protein 2
HGNC id	5247

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	head to head
text	located near the 5' flanking region of the CRYAB gene in a head to head orientation manner
STRUCTURE	1.36 kb     2 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001541 2 - 858 NP_001532 - 182 - 1997 9344664

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Endocrine thyroid       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose     predominantly Muscular striatum cardiac     Muscular striatum skeletal   moderately

cells

System Cell Pubmed Species Stage Rna symbol Muscular myoblast Muscular myocyte Reproductive oocyte Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an N terminus involved in multimerization
	a C terminus with the alpha crystallin domain responsible for chaperone function

conjugated

PhosphoP

HOMOLOGY

interspecies	ortholog to rattus Hspb2 (97.3pc)
	ortholog to murine Hspb2 (96.7pc)

Homologene

FAMILY	alpha crystallin/small hsp family
	small heat shock protein (HSP20) family

CATEGORY

chaperone/stress

SUBCELLULAR LOCALIZATION	plasma membrane,junction
	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,cytoplasm,cytoskeleton
	intracellular,nucleus,nucleoplasm
	intracellular,nucleus,chromatin/chromosome
	intracellular,nucleus,nucleolus
text	myofibrils, neuromuscular junctions

basic FUNCTION	potentially involved in chaperone activity
	involved in maintenance of cytoskeletal network in muscle (potential role in pathogenesis of myotonic dystrophy)
	acting as an enzyme activator
	protects hippocampal progenitor cells from glucocorticoid-induced apoptotic cell death
	role in regulating AKT1 activation and cellular apoptosis by mediating interaction between AKT1 and its upstream activator MAPKAPK2
	may be involved in the pathogenesis of myotonic dystrophy and contribute to the neuropathology in both Alzheimer disease and hereditary cerebral hemorrhage with amyloidosis, Dutch type
	ADP-induced phosphorylation of HSP27 via MAPK3 and/or MAPK14 is sufficient for platelet granule secretion but not for platelet aggregation
	chaperone of the myotonic dystrophy protein kinase, having a function as a novel inhibitor of apical caspase activation in the extrinsic apoptotic pathway
	inhibits the extrinsic apoptotic pathway by suppressing apical caspases-8 and 10 activation, thereby blocking downstream apoptotic events, such as BID cleavage and caspase-3 activation
	anti-apoptotic protein that negatively regulates apical caspase activation in the extrinsic apoptotic pathway
	may be playing a new role in the antiapoptotic action triggered by 17beta-estradiol by modulating CASP3 activity and stabilizing EESR2 in skeletal muscle cells
	facilitates the palmitoylation and plasma membrane translocation of the three classes of sex steroid receptors
	multifunctional protein that participates in ubiquitination of proteins for their degradation by proteasomes
	modulates HNRNPD proteolysis and AU-rich element-mediated mRNA degradation

CELLULAR PROCESS	cell life, differentiation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	complexing with HSPB3 during myogenic differentiation, but biochemical properties of the HSPB2/B3 complex are distinctly different from those of other small heat-shock proteins, indicating that the HSPB2/B3 assembly is likely to possess cellular functions other than those of its family members
	phosphorylated by the kinase mitogen-activated protein kinase-activated protein kinase 2

INTERACTION

DNA

RNA

small molecule

protein	binding and activating MDPK
	HSPB8
	interacts with estrogen receptors (ER) beta (ESR2) in mitochondria
	binds to a motif in estrogen receptor alpha (ESR1) and promotes palmitoylation of the steroid receptors
	facilitates the trafficking of endogenous ESR1 to the plasma membrane
	TGFB1I1 and HSPB1, HSPB2 are effectors of NOX4 required for TGFB1-stimulated Focal adhesions (FAs) formation, adhesion strength and migration in vascular smooth muscle cell
	EXOC3 is involved in the enhancement of cell migration and suppression of apoptosis through the activation of HSPB1, HSPB2 or MAPK14 phosphorylation

cell & other

REGULATION

induced by

not induced by heat shock

Other

phosphorylated by the kinase mitogen-activated protein kinase-activated protein kinase 2

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   confers long-lasting neuroprotection against ischemic brain injury via a previously unexplored association and inhibition of MAP3K5 signaling

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target	target for interrupting signaling from membrane sex steroid receptors to tumor biology in hormone-responsive cancers )

ANIMAL & CELL MODELS

downregulation of Hspb2 improved the maturation of mouse oocytes, while increased early stage of apoptosis in oocytes by inducing the activation of extrinsic, caspase 8-mediated pathway