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FLASH GENE
Symbol TALDO1 contributors: mct - updated : 14-05-2020
HGNC name transaldolase 1
HGNC id 11559
DNA
TYPE functioning gene
STRUCTURE 17.55 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
text structure
  • insertion of retrotransposable element
  • two translational initiation sites, generating two isoforms that differ by the presence of the first 10 N-terminal amino acids
  • MAPPING cloned Y linked   status confirmed
    Map pter - TALDO1 - D11S922 - cen
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1199 - 337 localized to the cell nucleus 2016 27703206
  • long isoform
  • unlike the short one, binds to importin alpha and is actively transported into the nucleus in an importin alpha/beta-dependent manner
  • - - - - 327 localized to cytoplasm 2016 27703206
  • short isoform
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousoligodendrocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to yeast transaldolase
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • transaldolase, key enzyme of the pentose phosphate pathway
  • transfers a dihydroxyacetone group from donor compounds (fructose 6-phosphate or sedoheptulose 7-phosphate) to aldehyde acceptor compounds
  • rate-limiting enzyme involved in the pentose phosphate pathway, which is traditionally thought to occur in the cytoplasm
  • nucleocytoplasmic distribution of TALDO1, modulated via alternative translational initiation and dimer formation, plays an important role in a wide range of metabolic networks
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) TALDOD
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS