protein
| associating with the anaphase promoting complex (APC), thereby inhibiting its ubiquitin ligase activity |
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ADAM17 |
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PCID2 is essential for B cell survival through the regulation of MAD2L1 expression during B cell differentiation |
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although MAD2L1BP binds to MAD2L1, it promotes the dissociation of CDC20 from BUB1B in MCC |
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interacting with MAD1L1 (recruitment of the spindle-assembly checkpoint protein MAD2L1, through MAD1L1, to non-bioriented kinetochores is needed to stop cell-cycle progression) |
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interacting with CDC20 (key event during spindle assembly checkpoint activation) |
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CHFR interact with MAD2L1, an important component of the spindle assembly checkpoint, where CHFR knockdown resulted in mislocalization of MAD2L1 and disruption of the MAD2L1/CDC20 interaction |
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direct interaction between BUB1B and MAD2L1 and the interaction plays critical roles in mitotic checkpoint complex-mediated inhibition of anaphase-promoting complex/cyclosome (APC/C) |
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SGOL2 specifically interacts with MAD2L1 in a manner that strongly resembles the interactions of MAD2L1 with MAD1L1 or CDC20 |
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binding of MAD2L1BP to MAD2L1 in mitotic checkpoint complex (MCC) may trigger a conformational change in CDC20 that facilitates its phosphorylation by CDK, and the latter process may promote its dissociation from BUB1B |
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MAD2L1 competes directly for CDC20 with the anaphase-promoting complex/cyclosome (APC/C), which would contribute to the rapid and potent inhibition of CDC20 |
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stable interaction of CDC20 with MAD2 is required to maintain spindle assembly checkpoint (SAC) signaling |
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promotes efficient mitotic exit, specifically the metaphase-anaphase transition, by antagonizing MAD2L1 function |
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TPR is required for normal SAC response by stabilizing MAD1L1 and MAD2L2 before mitosis |
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MAD2L1BP is an antagonist of the SAC effector MAD2L1 and promotes silencing of the SAC and mitotic progression |
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CHEK1 is required for the metaphase-anaphase transition via regulating the subcellular localization and the expression of CDC20 and MAD2L1 |
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WT1 regulates the mitotic checkpoint complex (MCC) by directly interacting with the spindle assembly checkpoint protein, MAD2L1 |
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UBD play a role in mitotic regulation through its interaction with mitotic arrest-deficient 2 (MAD2L1) |
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interaction of UBD with MAD2L1 is a key mechanism underlying the promalignant property of UBD and offer prospects for the development of anticancer strategies |
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MAD2L1BP is a MAD2L1-interacting protein that serves as a spindle checkpoint silencer at mitosis |
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MAD1L1 plays a minor role in influencing the MAD2L1-dependent regulation of AURKB suggesting that the effects of MAD2L1 on AURKB are independent of the spindle checkpoint complex |
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unexpected dependency on TRIP13 in cells overexpressing MAD2L1 |
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TRIP13 regulates both MAD2L1 and meiotic HORMAD1, HORMAD2 by disassembling these HORMA domain-closure motif complexes |
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TRIP13-MAD2L1BP intercepts and disassembles free MCC not bound to anaphase-promoting complex/cyclosome (APC/C) through mediating the local unfolding of the MAD2L1 C-terminal region |