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FLASH GENE
Symbol TOR1B contributors: mct - updated : 14-04-2006
HGNC name torsin family 1, member B (torsin B)
HGNC id 11995
DNA
TYPE functioning gene
STRUCTURE 8.12 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
regionally located tightly linked to TOR1A in opposite orientation
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   moderately
Nervousbrainbasal nuclei  lowly
 brainlimbic systemhippocampus  
Reproductivemale systemprostate  highly
Respiratorylung   moderately
Skin/Tegumentskin   highly
Urinarykidney   moderately
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousdopaminergic neuron
NervousPurkinje cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
intraspecies homolog to TOR1A
Homologene
FAMILY AAA family chaperone-like (adenosine triphosphatases associated with diverse cellular activities)
CATEGORY chaperone/stress
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,organelle,lumen
intracellular,cytoplasm,organelle,endoplasmic reticulum
intracellular,nuclear envelope
text perinuclear in some neurons
basic FUNCTION
  • potentially involved in synaptic functioning
  • may serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins
  • needed for developmental events occurring in the early postnatal phase and is necessary for functional activity throughout life
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS