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FLASH GENE
Symbol MAFG contributors: mct/npt - updated : 04-10-2016
HGNC name v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)
HGNC id 6781
DNA
TYPE functioning gene
STRUCTURE 9.00 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
text variants 1 and 2 encode the same protein
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 5043 17 162 - Yamamoto (2006)
- - 5038 17 162 - Yamamoto (2006)
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Endocrineparathyroid   highly
Nervousbrain    
Reproductivefemale systemuteruscervix highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone  highly
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a basic region-leucine zipper motif through which they form homodimers or heterodimers with SLC8A1 and ACOT7 proteins
  • MAFG C terminus is required for NFE2 function, suggesting that efficient targeting of NFE2 to a specific nuclear scaffold is important to achieve high-level activity
  • mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies homolog to avian musculoaponeurotic fibrosarcoma (v-maf) oncogene
    intraspecies homolog to mafk
    Homologene
    FAMILY
  • bZIP transcription factors family
  • Maf subfamily
  • CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • transcriptional activator by dimerzing with other basic zipper proteins
  • regulate expression and induction of detoxifying enzyme genes including quinone oxidoreductase
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimerizing with NFE2 to form an erythroid and megakaryocytic cell specific transcription factor
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MAFG is required only for NFE2 binding to Maf recognition element (MARE) and to facilitate NFE2-mediated transcriptional activation
  • cell & other
    REGULATION
    induced by stress
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS