SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,membrane
|
| intracellular,cytoplasm,organelle,Golgi
|
| intracellular,cytoplasm,organelle,endosome
|
text
| after internalization, it appears that FZD5 is recycled back to the plasma membrane |
basic FUNCTION
| exhibiting characteristics of a WNT receptor |
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involved in signal transduction |
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may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues |
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WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation |
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functioning as WNT5A receptor, and key molecule in the fields of oncology |
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central role for FZD5 signaling in mammalian eye development and are likely to be relevant to the etiology of congenital human ocular anomalies |
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mediates the synaptogenic effect of WNT7A and its localization to synapses is regulated by neuronal activity, a process that depends on endogenous Wnts |
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FZD5 and FZD8 are involved in dose-dependent regulation of signaling in optic fissure/disc formation and progenitor expansion |
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GCM1 and FZD5 function in an evolutionary conserved positive feedback loop that regulates trophoblast differentiation and sites of chorionic branching morphogenesis |
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potential role of FZD5 in neuronal polarization |
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has a role in the establishment of neuronal polarity, and in the morphogenesis of neuronal processes, in part through the activation of the non-canonical Wnt mechanism involving JNK |
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conserved role of Wnt-Frizzled (FZD) signaling in ocular development and directly implicate WNT-FZD signaling both in normal closure of the optic fissure and pathogenesis of coloboma |