basic FUNCTION
| putatively involved in Cu homeostasis and copper during embryonic development |
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oligomeric form acts as a conventional transporter providing a permeation pathway for Cu through the membrane and internalization of endogenous form in response to elevated extracellular Cu levels does not play a significant regulatory role in Cu homeostasis (Eisses 2005) |
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plays a key role in the physiologically important delivery of copper from blood to intracellular proteins, whereas its role in the initial apical uptake of dietary copper is indirect (Zimnicka 2007) |
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creates a pore that stretches across the membrane bilayer at the interface between the subunits (the second transmembrane helix is the key element lining the pore, and important residues on this helix could participate in Cu(I)-coordination during transport) (De Feo 2009) |