basic FUNCTION
| regulator of hepatocyte specific genes |
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may be involved in epithelial cell differentiation of gut endoderm |
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participating to the control of organ development from the forgut and midgut endoderm |
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inhibiting the glucocorticoid-induced stimulation of two genes of the glucose metabolism |
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stimulating hepatocyte nuclear factor 3B and TTR promoter |
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antagonizing 6 phosphofructo-2-kinase (PFKFB1), PEPCK (PCK1, PCK2) |
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ONECUT2 and ONECUT3 play redundant roles with ONECUT1 in pancreas development |
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required during embryogenesis for pancreatic specification, morphogenesis and endocrine differentiation |
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key regulatory factor in pancreatic development, endocrine differentiation and the formation of the biliary tract, as well as glucose metabolism |
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has both early and late functions in the developing pancreas and is essential for maintenance of NEUROG3 expression and proper pancreatic duct morphology |
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one of liver-enriched transcription factors |
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its function is correlated to cell proliferation, cell cycle regulation, cell differentiation and organogenesis, cell migration and cell-matrix adhesion, glucose metabolism, bile homeostasis, inflammation |
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ONECUT1, ONECUT2, ONECUT3 are required at early developmental stages for differentiation of the mesencephalic trigeminal nucleus neurons that are in turn necessary for maintenance of the Locus Coeruleus |
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role in the control of normal beta cell differentiation and its involvement in beta cell dysfunction under diabetic conditions by suppressing MAFA gene expression |
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ONECUT1, ONECUT2 redundantly regulate early retinal cell fates during development |
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ONECUT1 transcription factor is a factor that influences the gene regulatory networks specific to cones and rods, but not those that are common to both. |
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is an important regulator of both duct and acinar cell development in the embryonic pancreas |
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ONECUT1, ONECUT2 are involved in dose-dependent regulation of retinal horizontal cell fate |
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OTX2, ONECUT1 and possibly other Onecut proteins have likely a broad role in coordinating cone development and function |
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controls a transcriptional and epigenetic machinery regulating endocrine development, involved in a spectrum of diabetes |
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is a crucial fate regulator in pancreas progenitors and likely is also involved in preparing pancreatic progenitors for later endocrine specification |