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FLASH GENE
Symbol NUP88 contributors: mct/npt/pgu - updated : 06-07-2010
HGNC name nucleoporin 88kDa
HGNC id 8067
DNA
TYPE functioning gene
STRUCTURE 33.58 kb     17 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map pter - C1QBP - D17S2014 - NUP88 ,D17S1662 - D17S938 - cen
Physical map
TM4SF5 17p13.3 transmembrane 4 superfamily member 5 LOC284013 17p13.3 secretory protein LOC284013 LOC388323 17 similar to RIKEN cDNA C730027E14 PSMB6 17p13 proteasome (prosome, macropain) subunit, beta type, 6 PLD2 17p13.1 phospholipase D2 LOC284015 17p13.3 similar to Vacuolar ATP synthase 16 kDa proteolipid subunit MINK 17p13 similar to Vacuolar ATP synthase 16 kDa proteolipid subunit CHRNE 17p13.1 cholinergic receptor, nicotinic, epsilon polypeptide GP1BA 17pter-p12 glycoprotein Ib (platelet), alpha polypeptide SLC25A11 17p13.3 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 DKFZP566H073 17p13.3 DKFZP566H073 protein PFN1 17p13.3 profilin 1 ENO3 17pter-p12 enolase 3, (beta, muscle) SPAG7 17p13.2 sperm associated antigen 7 CAMTA2 17p13.3 calmodulin binding transcription activator 2 LOC388324 17 LOC388324 KIF1C 17p13 kinesin family member 1C FLJ10060 17p13.3 putative G-protein coupled receptor GPCR42 FLJ30726 17p13.3 hypothetical protein FLJ30726 ZNF232 17p13-p12 zinc finger protein 232 USP6 17q11 ubiquitin specific protease 6 (Tre-2 oncogene) KIAA1871 17p13 KIAA1871 protein LOC388325 17 similar to DTFT5783 RABEP1 17p13.1 rabaptin, RAB GTPase binding effector protein 1 NUP88 17p13.2-p13.1 nucleoporin 88kDa MGC4189 17p13.3 hypothetical protein MGC4189 C1QBP 17p13.3 complement component 1, q subcomponent binding protein DHX33 17p13.2 DEAH (Asp-Glu-Ala-His) box polypeptide 33 F-LANa  carcinoma related gene MIS12 17p13.3 homolog of yeast Mis12 LOC388326 17 similar to Death effector filament-forming Ced-4-like apoptosis protein NALP1 17p13 NACHT, leucine rich repeat and PYD containing 1 LOC390759 17 similar to NipSnap1 protein
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
17 polyA site 2381 85 741 - 1997 9049309
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis  highly
Urinarykidneynephronrenal capsule  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • coiled-coil domain, an interaction domain often founded in NPC proteins
  • HOMOLOGY
    interspecies homolog to murine Prei2
    Homologene
    FAMILY Ezrin/radixin/moesin family
    CATEGORY structural protein , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nuclear envelope,pore
    text
  • localized on the spindles together with NUP214 during mitosis
  • localizes to the cytoplasmic and nuclear face of the nuclear pore complexes (
  • basic FUNCTION
  • having a dichotomous role in non-neoplastic and neoplastic conditions of the liver
  • its proper expression is critical for preventing aneuploidy formation and tumorigenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text birectional nucleocytoplastic transport
    PATHWAY
    metabolism
    signaling
    a component
  • nuclear pore complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding CAN/NUP214 and XPO1 (CRM1)
  • requested for NPC location
  • interacting with NFAT5 (up-regulated in response to hypertonic stress and acts to retain NFAT5 in the nucleus, activating transcription of critical osmoprotective genes)
  • binds lamin A (interaction is mediated by the N-terminus of NUP88, and NUP88 specifically binds the tail domain of lamin A but not of lamins B1 and B2)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in response to osmotic stress in inner medullary collecting duct (IMCD3) cells
    constitutional     --over  
    enhanced multinucleated cell formation
    tumoral     --over  
    in high-grade cervical intraepithelial neoplasia (CIN1) lesions and invasive squamous cell carcinoma compared with normal ectocervical squamous epithelia and CIN1
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS