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FLASH GENE
Symbol C5AR1 contributors: npt/ - updated : 02-03-2006
HGNC name complement component 5a receptor 1
HGNC id 1338
DNA
TYPE functioning gene
STRUCTURE 12.22 kb     2 Exon(s)
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 2342 - 350 - -
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticeosinophil
cell lineage
cell lines
fluid/secretion blood
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments (7TM) receptor, forming seven helices
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine C5r1
    Homologene
    FAMILY
  • G protein coupled receptor 1 family
  • CATEGORY immunity/defense , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • C5A (anaphylatoxin) receptor
  • stimulating chemotoxics, granule enzyme release and superoxide anion and participating in the defense of choroidal and retinal tissues during inflammation
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS immunity/defense
    text communication motility increasing polarization and migration
  • required formucosal bacterial defense in the lung
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • enhancing C5a-mediated release of IL8 upon exposure to cigarette smoke
  • interacting with RGS3 (in apoptosis-initiated cells, the ligand-dependent C5AR1-mediated dual signal affects the fate of cells, either apoptosis execution or survival, through regulation of RGS3 gene expression and subsequent modulation of ERK signal (Nishiura 2009)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene in antiphospholipid syndrome (MIM107320)(Gilardi(03))
    Marker
    Therapy target
    ANIMAL & CELL MODELS