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FLASH GENE
Symbol PA2G4 contributors: mct - updated : 29-03-2008
HGNC name proliferation-associated 2G4, 38kDa
HGNC id 8550
DNA
TYPE functioning gene
STRUCTURE 9.59 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 2643 42 394 only in the cytoplasm 2010 21098709
  • p42
  • specifically associates with NPM1 upon epidermal growth factor stimulation
  • - - - 48 - . localizes in both the cytoplasm and the nucleolus 2010 21098709
  • constantly binds NPM1
  • constitutively binds NPM1 in the nucleolus, for which B23 Lys263 sumoylation is indispensable
  • is transforming and promotes cell growth, clonogenicity, and invasion in human glioblastoma (GBM)
  • functions as an oncogene by promoting glioma tumorigenicity via interactions with HDM2 that contribute to TP53 downregulation
  • EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
     pharynx   highly
    Lymphoid/Immunetonsils   highly
    Reproductivefemale systemuteruscervix highly
     female systemovary  highly
    Skin/Tegumentskin   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    cell cycle     cell cycle, S, checkpoint, G1S
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine cell-cycle P38-2G4
    homolog to murine Plfap
    Homologene
    FAMILY
  • metallopeptidase family
  • peptidase m24c family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleolus
    text confined to the nucleus during interphase and cytoplasmic from metaphase through to telophase
    basic FUNCTION
  • RNA-binding protein that is involved in growth regulation
  • involved in the control of cell replication
  • potent repressor of androgen receptor signaling
  • CELLULAR PROCESS cell cycle, division
    cell life, differentiation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of cytoplasmic BCL-2 mRNP (messenger ribonucleoprotein particle) complexes
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ERBB3 binding protein (role in maintaining AR protein level)
  • interacting with AR (associated with the N-terminal domain of AR)
  • interaction with NPM1 (distinctively binds isoforms and regulates cell proliferation and survival through p42 and p48, respectively)
  • RNF20 acts as an E3 ubiquitin ligase for PA2G4 tumor suppressor and promotes its polyubiquitination and degradation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in prostate cancer (androgen-independent)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    therapeutic target for treatment of hormone refractory prostate cancer
    ANIMAL & CELL MODELS