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FLASH GENE
Symbol PDLIM4 contributors: mct - updated : 19-03-2010
HGNC name PDZ and LIM domain 4
HGNC id 16501
DNA
TYPE functioning gene
STRUCTURE 15.80 kb     7 Exon(s)
regulatory sequence Promoter
text structure two putative transcription start points (tsp)
MAPPING cloned Y linked N status confirmed
Map cen - IL4 - IL13 - RAD50 - IL5 - IRF1 - PDLIM4 - IL3 IL3 - qter
RNA
TRANSCRIPTS type messenger
text with an alternative transcript missing exon six and the LIM domain (PMID: 9573374)
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 splicing 2307 35.4 330 - 1998 9573374
6 splicing 2189 25.9 246 brain 1998 9573374
6 splicing - - 246 - 2011 21636573
  • shorter alternatively spliced isoform, intrinsically unstable due to an unstructured region at its C terminus, with a PEST motif that can destabilize heterologous target proteins
  • lacks the sequence of exon 6
  • degraded by the core 20 S proteasome
  • affects actin organization via interaction with full-length PDLIM4
  • functions as a dominant-negative modulator of PDLIM4-mediated actin reorganization
  • accumulates particularly in response to oxidative stress
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    digestivemouthgingiva   
    Nervousbrain    
    Reproductivemale systemprostate   
    Respiratorylung    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two N-terminal cysteine-rich LIM/double zinc finger motifs (LIM domains)
  • a PDZ/DHR domain
  • HOMOLOGY
    interspecies homolog to rattus Ril 1
    ortholog to murine Ril-pending
    Homologene
    FAMILY
  • ALP/Enigma family of PDZ and LIM domain-containing adapter proteins
  • CATEGORY transcription factor , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may be involved in intracellular signaling cascade
  • PDZ-LIM protein acting as a regulator of actin stress fiber turnover
  • frequently lost in colon and other cancers as a result of epigenetic silencing, suppresses Src activation
  • may function as a tumor suppressor, involved in the control of cell proliferation by associating with actin in prostate cancer cells
  • implicated in regulation of actin stress fiber turnover
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    intracellular signaling cascade
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • associated with alpha-actinin via its PDZ domain
  • interacting with PTPN13 and SRC (suppresses SRC activation through interacting with SRC and PTPN13, allowing PTPN13-dependent dephosphorylation of SRC at the activation loop)
  • direct interaction of PDLIM4 with F-actin
  • binds to alpha-actinin, enhances its ability to interact with actin filaments, and promotes formation of actin stress fibers
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    by hypermethylation in renal cell carcinoma
    tumoral     --low  
    by hypermethylation in acute myelogenous leukemia and colon cancer (60 p100 of cases)
    Susceptibility to osteoporosis
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    good candidate tumor suppressor gene silenced by hypermethylation in cancer
    ANIMAL & CELL MODELS