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FLASH GENE
Symbol CSRP1 contributors: - updated : 21-08-2007
HGNC name cysteine and glycine-rich protein 1
HGNC id 2469
DNA
TYPE functioning gene
STRUCTURE 23.00 kb     6 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
 stomach   highly
Nervousbrain   highly
Reproductivefemale systemuteruscervix highly
cell lineage
cell lines
fluid/secretion
at STAGE
Text in the endoderm underlying cardiac mesoderm and a restricted region of cardiac mesoderm, in the mesendoderm and notochord
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two N terminal cysteine rich LIM/double zinc finger motifs (LIM domains)
  • a glycine-rich repeat
  • HOMOLOGY
    interspecies homolog to murine Csrp
    Homologene
    FAMILY CSRP family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • expressed by a serum-inducible immediate response gene
  • likely involved in the determination of cell lineage and regulation of cell differentiation
  • being an essential factor that connects the noncanonical Wnt signals to cell behaviors and migration
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of complexes that control integrin-dependent cell migration of mesendoderm and cardiac mesoderm cells
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with ANKRD6 and DVL2
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    loss of Csrp1 function results in cardiac bifida in the mouse