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FLASH GENE
Symbol CYP4A11 contributors: mct - updated : 06-06-2007
HGNC name cytochrome P450, family 4, subfamily A, polypeptide 11
HGNC id 2642
DNA
TYPE functioning gene
STRUCTURE 12.00 kb     12 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   lowly
Urinarykidney   lowly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated HemoP
mono polymer monomer
HOMOLOGY
interspecies homolog to dog CYP4A11 (78.39 pc)
homolog to rattus Cyp4a10 (77.56 pc)
homolog to murine Cyp4a10 (77.56 pc)
intraspecies homolog to CYP4A22
Homologene
FAMILY
  • cytochrome P450 subfamily IVA
  • multigenic cytochrome P450 superfamily of mixed-function monooxygenases
  • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • hydroxylation of medium chain fatty acid such as laurate and myristate
  • responsible for the omega-hydroxylation of phytanic acid
  • involved in the balance of lipids
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
    NADPH, heme
    protein flavoprotein P450 oxidoreductase (POR)
    cell & other
    REGULATION
    repressed by retinoic acid in liver cells (suppression of CYP4A11 expression by retinoids could have a major impact on fatty acid metabolism in the liver)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS