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FLASH GENE
Symbol SH3GL2 contributors: mct - updated : 26-09-2015
HGNC name SH3-domain GRB2-like 2
HGNC id 10831
DNA
TYPE functioning gene
STRUCTURE 217.00 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainforebraincerebral cortex  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text cerebellum
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a putative nuclear localization signal, potential tyrosine phosphorylation sites,
  • a Bin/Amphiphysin/Rvs (BAR) domain responsible for membrane bending, and an SH3 domain responsible for the recruitment of dynamin and synaptojanin, two proteins involved, respectively, in the fission and uncoating of clathrin-coated vesicles
  • putative SH2-, SH3-, and PTB-binding sites
  • C-terminal SH3 domain
  • HOMOLOGY
    intraspecies homolog to Src-homology 3 domain GRB2-like gene 2
    Homologene
    FAMILY endophilin family.
    CATEGORY adaptor , transport
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text peripheral membrane protein. concentrated in presynaptic nerve terminals in neurons.
    basic FUNCTION
  • playing a role in synaptic vesicle recycling, in particular in clathrin-mediated vesicle endocytosis
  • novel function of postsynaptic SH3GL2 in spine morphogenesis, stabilization and synaptic function through the regulation of SRCIN1
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , cellular trafficking transport
    PATHWAY
    metabolism
    signaling signal transduction
    a component complexing with signalling molecules, including cell surface receptors, metalloprotease disintegrins and germinal centre kinase-like kinase (GLK)
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with SYNJ1 and DNM1
  • PSD interacting with SH3GL2 that stimulates the catalytic activity of PSD on ARF6
  • SRCIN1, a regulator of cytoskeleton reorganization, is a downstream effector of SH3GL2 and disruption of their interaction impairs spine formation and maturation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS