basic FUNCTION
| playing an important role in cellular stress response to ultraviolet radiation (UVR) |
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having apoptotic functions may be exerted by chromatin-related functions that are subject to cell age-dependent mechanisms of regulation |
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involved in the regulation of diverse processes ranging from cell cycle and cellular senescence to apoptosis |
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inducing cell-cycle arrest and apoptosis in a TP53-dependent manner |
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potentially regulate the expression of proteins that are critical for angiogenesis in glioblastoma such as the angiopoietins |
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affect apoptosis, growth, and DNA repair by binding histones and regulating chromatin structure and gene expression |
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critical epigenetic regulator of cellular senescence in human fibroblasts |
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stabilizes TP53 by inhibiting polyubiquitination of multimonoubiquitinated forms via interaction with and colocalization of the USP7-deubiquitinase with TP53 |
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ING1-RSL1D1 axis functions as a novel pro-apoptotic regulator in response to DNA damage |
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acts likely at early stages of the DNA damage response activating a variety of repair mechanisms and that this function of ING1 is targeted in tumors. |
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functions as an epigenetic regulator and a type II tumor suppressor |
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role for ING1b SUMOylation in the regulation of gene transcription |
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regulates the nucleolar epigenome and rDNA transcription suggesting that regulation of protein synthesis might serve as the basis for ING1 function as a type II tumor suppressor |
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functional role for the epigenetic regulator ING1 in activity-induced gene expression in primary cortical neurons |