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FLASH GENE
Symbol HRH2 contributors: - updated : 23-08-2007
HGNC name histamine receptor H2
HGNC id 5183
DNA
TYPE like-sequence
STRUCTURE 1.00 kb     1 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
text structure
  • multiple transcription initiation sites and tissue specific expression
  • MAPPING cloned Y linked   status provisional
    Physical map
    GAPDL16 5q33.1-q35.3 glyceraldehyde-3-phosphate dehydrogenase-like 16 MSX2 5q35.1 msh homeo box homolog 2 (Drosophila) DRD1 5q35.1 dopamine receptor D1 SFXN1 5q35.3 sideroflexin 1 HRH2 5q35.3 histamine receptor H2 CPLX2 5q35.1-q35.3 complexin 2 LOC389346 5 similar to hypothetical protein THOC3 5q35.2-q35.3 THO complex 3 LOC391851 5 similar to olfactory receptor MOR126-1 LOC389347 5 similar to NY-REN-7 antigen LOC391852 5 similar to MGC68922 protein LOC391853 5 similar to selenophosphate synthetase 1 FLJ44216 5q35.3 FLJ44216 protein KIAA1191 5q35.3 KIAA1191 protein MGC2198 5q35.3 hypothetical protein MGC2198 FLJ39249 5q35.3 ADP-ribosylation factor-like membrane-associated protein HSPC111 5q35.3 hypothetical protein HSPC111 CLTB 4q2-q3 clathrin, light polypeptide (Lcb) ETEA 5q35.3 expressed in T-cells and eosinophils in atopic dermatitis RNF44 5q35.3 ring finger protein 44 PC-LKC 5q35.3 protocadherin LKC KIAA1893 5q35.3 G protein-regulated inducer of neurite outgrowth 1 SNCB 5q35 synuclein, beta LOC253314 5q35.3 similar to eukaryotic translation initiation factor eIF4E-1 MGC14859 5q35.3 hypothetical protein MGC14859 LOC389348 5 LOC389348 KIAA1976 5q35.3 netrin receptor Unc5h1 HK3 5q35.2-q35.3 hexokinase 3 (white cell) RAP80 5q35.3 receptor associated protein 80
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Skin/Tegumentskin    
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven transmembrane (7TM) domains
  • HOMOLOGY
    Homologene
    FAMILY G protein coupled receptor superfamily
    CATEGORY receptor G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • activating adenylate cyclase
  • increasing contraction of cardiac muscle
  • stimulating gastric acid secretion
  • involved in the regulate gastrointestinal motility and intestinal secretion
  • possible role in regulating cell growth and differentiation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS