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FLASH GENE
Symbol SLC1A3 contributors: mct - updated : 22-05-2014
HGNC name solute carrier family 1 (glial high affinity glutamate transporter), member 3
HGNC id 10941
DNA
TYPE functioning gene
STRUCTURE 81.98 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
text structure
  • promoter comprises the 2.3 kb region immediately flanking the prime-end of the SLC1A3 gene
  • species-specific function of the SLC1A3 3prime-UTR in constitutive and regulated SLC1A3 expression
  • MAPPING cloned Y linked   status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 4188 - 542 - 1995 7698014
    2 - 1376 - 65 - 1995 7698014
    8 - 3670 - 497 - 1995 7698014
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Nervousbrainforebraincerebral cortex highly Homo sapiens
     nervecranial nerve  highly
     spinal cord    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousastrocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • ten transmembrane spanning segments (mutations in transmembrane domains 5 and 7 affect the substrate-activated anion), and some AAs of TM5 take part in the transport pathway during the transport cycle
  • a type I PDZ domain-binding motif
  • six N terminal and cytoplasmic N and C termini
  • HOMOLOGY
    Homologene
    FAMILY
  • sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family
  • SLC1A3 subfamily
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    text
  • is expressed in myocardial mitochondria, and functions in the malate/aspartate shuttle
  • co-localized with SLC9A3R2 in ER–Golgi intermediate compartments (ERGICs), at the plasma membrane and in early endosomes, but not in the ER
  • basic FUNCTION
  • Na+ (and K+) dependent glutamate transporter, involved in development and neonatal hypoxic-ischemic damage
  • glial high affinity glutamate/aspartate transporter in the cerebellum
  • playing an essential role for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft
  • may be playing a role in myocardial glutamate metabolism
  • playing a necessary role for brain development through regulation of extracellular glutamate concentration
  • major role, both in protecting the synapse from exposure to excess extracellular glutamate and in attenuating hearing loss due to acoustic overstimulation
  • allows significant passive and active water transport, which suggests that water permeation through glutamate transporters may play an important role in glial cell homoeostasis
  • does not only mediate secondary-active glutamate transport, but also functions as an ion channel
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SLC9A3R1 interacts with SLC1A3 during ER export, while SLC9A3R2 interacts with SLC1A3 in the secretory pathway from the ERGIC to the plasma membrane, thereby modulating the cell surface expression of SLC1A3
  • TNR is likely expressed in a subset of astrocytes and contributes to glutamate homeostasis by regulating astrocytic SLC1A3 expression
  • CAV1 is a powerful negative regulator of the excitatory glutamate transporters SLC1A1, SLC1A2, SLC1A3, SLC1A6
  • cell & other
    REGULATION
    activated by KL that up-regulates the excitatory glutamate transporters SLC1A3 and SLC1A2 and thus participates in the regulation of neuronal excitation
    ASSOCIATED DISORDERS
    corresponding disease(s) EA6
    related resource MITOP database
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in motor neuron disease
    constitutional     --low  
    may be an adaptive response to neuronal death or it may be a causative event contributing to neuronal death
    constitutional     --low  
    reduced SLC16A4 and SLC1A3 expression by astrocytes may lead to neuronal hyperexcitability and epileptogenesis in the temporal lobe by reducing the supply of metabolic intermediates and by allowing accumulation of extracellular glutamate
    Susceptibility
    Variant & Polymorphism
    Candidate gene its expression is exceptionally rare in non-neoplastic choroid plexus and is a helpful diagnostic tool in choroid plexus tumors
    Marker
    Therapy target
    ANIMAL & CELL MODELS