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FLASH GENE
Symbol TNFSF4 contributors: mct - updated : 09-02-2008
HGNC name tumor necrosis factor (ligand) superfamily, member 4 (tax-transcriptionally activated glycoprotein 1, 34kDa)
HGNC id 11934
DNA
TYPE anonymous DNA segment
STRUCTURE 23.00 kb     3 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Map cen - DNM3 - PIGC - C1orf9 - FASLG - TNFSF18 - TNFSF4 - PRDX6 - KLHL20 - SERPINC1 - MRPS14 - TNN - TNR - qter
Authors Wang(05)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 3510 - 183 - Liu (2007)
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Lymphoid/Immunelymph node    
Respiratoryrespiratory tractlarynx   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneT cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
an extracellular C terminus
conjugated GlycoP
mono polymer homomer , trimer
HOMOLOGY
interspecies homolog to murine Tnfsf4
Homologene
FAMILY tumor necrosis factor (ligand) superfamily
CATEGORY regulatory , signaling
SUBCELLULAR LOCALIZATION     plasma membrane
text type II transmembrane glycoprotein (TM1)
basic FUNCTION
  • playing a role in regulating immune responses
  • involved in T cell antigen-presenting cell (APC) interactions
  • required on activated CD4+ and CD8+ T cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein TNFRSF4 ligand (with its receptor directly mediate adhesion of activated T cells to vascular endothelial cells)
    cell & other
    REGULATION
    induced by on activated CD4+ and CD8+ T cells, and its expression is enhanced by TGF-beta1
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    predisposes to SLE either by quantitatively augmenting T cellAPC interaction or by influencing the functional consequences of T cell activation via TNFRSF4
    Susceptibility
  • to atherosclerosis, myocardial infarction
  • to systemic lupus erythematosus (SLE)
  • Variant & Polymorphism SNP
  • SNP increasing the risk of atherosclerosis, myocardial infarction
  • Candidate gene target for atherosclerosis therapy
    Marker
    Therapy target
    ANIMAL & CELL MODELS