basic FUNCTION
| involved in normal ovulation |
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oocyte secreted paracrine factor essential for mammalian ovarian folliculogenesis (Mottershead 2008) |
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may have a role in fertility (Mottershead 2008) |
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GDF9 and BMP15 are likely germ cell-specific factors in the testis, and GDF9 can modulate key Sertoli cell functions |
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may have functions in human preantral follicles |
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play likely roles in corpus luteum activity |
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crucial role of GDF9 and BMP15 in female fertility |
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BMP15 and GDF9 promoted activation of human primordial follicles from girls/women in a dose-dependent manner, but GDF9 seems more beneficial |
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GDF9 and bone morphogenetic protein 15 (BMP15) are two proteins selectively expressed in the oocyte which are essential for normal fertility |
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controls granulosa cell growth and differentiation during early ovarian folliculogenesis and regulates cumulus cell function and ovulation rate in the later stages of this process |
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GDF9 and bone morphogenetic protein 15 (BMP15) act synergistically to regulate granulosa cell proliferation and steroid production |
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GDF9 and BMP15 act synergistically to stimulate granulosa cell proliferation, a response that also involves species-specific non-SMAD signalling pathways |