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FLASH GENE
Symbol PRKX contributors: mct/pgu - updated : 06-09-2010
HGNC name protein kinase, X-linked
HGNC id 9441
DNA
TYPE functioning gene
STRUCTURE 109.26 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 6084 40.9 358 - 2002 12082174
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
Reproductivefemale systemuterus  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal highly
cell lineage
cell lines
fluid/secretion
at STAGE
Text
  • restricted to the ureteric bud epithelium of the fetal metanephric kidney
  • expressed in multiple developing tissues
  • abundant in fetal brain, kidney, and liver tissues compared with adult
  • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a AGC-kinase C-terminal domain
  • a protein kinase domain
  • HOMOLOGY
    interspecies homolog to Drosophila DC2 kinase
    Homologene
    FAMILY
  • protein kinase superfamily
  • AGC Ser/Thr protein kinase family
  • cAMP subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • may regulate epithelial morphogenesis during mammalian kidney development, and plays a role in cellular migration
  • can modulate the cAMP-mediated signal transduction pathway by preferential binding to the regulatory subunit type I (RIalpha) of cAMP-dependent protein kinase and by phosphorylating the type II regulatory subunit in the absence of cAMP
  • stimulates epithelial branching morphogenesis by activating cell migration and support a role for this kinase in the regulation of nephrogenesis and of collecting system development in the fetal kidney
  • with SMAD6 are required for PMA-induced cell attachment and spreading
  • signal-transduction protein required for macrophage differentiation
  • can restore normal function to PKD1-deficient kidneys and have implications for the development of preventative therapy for PKD1
  • cAMP-dependent kinase, regulator of epithelial morphogenesis during kidney development
  • stimulates endothelial cell proliferation, migration, and vascular-like structure formation, which are the three essential processes for angiogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to and phosphorylates Polycystin-1 (PKD1)
  • interacting with PKD1 and PIN1 (may mediate the function of PRKX in kidney development)
  • interaction of PRKX with PIN1, MAGI1 and BAG3 could contribute to the stimulating role of PRKX in angiogenesis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    aberrant adult kidney expression in autosomal dominant polycystic kidney disease
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS