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FLASH GENE
Symbol GLUD2 contributors: mct - updated : 15-03-2022
HGNC name glutamate dehydrogenase 2
HGNC id 4336
DNA
TYPE functioning gene
STRUCTURE 2.48 kb     1 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
1 - 2485 61 558 - 2010 20194501
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineadrenal glandcortex    Homo sapiens
Nervousbrainbasal nucleistriatum   Homo sapiens
 brainhindbraincerebellum predominantly Homo sapiensAdult
 brainforebraincerebral cortex   Homo sapiens
Reproductivemale systemtestis  highly Homo sapiens
Urinarykidneytubuleconvoluted tubule   Homo sapiensAdult
Visualeyeretina  highly Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelial     Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousastrocyte Homo sapiens
NervousPurkinje cell Homo sapiensAdult
ReproductiveSertoli cell Homo sapiens
Urinaryepithelial cell Homo sapiensAdult
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • Glu/Leu/Phe/Val dehydrogenases family
  • CATEGORY adhesion , enzyme , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    text localizes mainly to mitochondria and to a lesser extent to the endoplasmic reticulum of these cells
    basic FUNCTION
  • involved in the detoxification of transmitter glutamate
  • enzyme central to the metabolism of glutamate that also plays a role in cellular energetics
  • having importance for nerve tissue biology
  • in the kidney, could contribute to enhanced excretion of ammonia under acidosis
  • GLUD2 is not only an adhesion molecule at synapses but also works as a channel
  • role for GLUD1, GLUD2 at excitatory synapses in neuronal networks throughout the adult brain
  • synaptic connection in the adult brain can regenerate with aid of GLUD2
  • regulates synapse formation and regeneration, synaptic plasticity, and motor learning
  • CBLN1 and postsynaptic receptor GLUD2 mediate synaptogenesis between granule cells and Purkinje cells in the molecular layer of the cerebellar cortex
  • GLUD1 and GlUD2 exhibit the molecular architecture of postsynaptic ionotropic glutamate receptors, but assemble into trans-synaptic adhesion complexes by binding to secreted cerebellins that in turn interact with presynaptic neurexins
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism aminoacid
    signaling
    a component CBLN1-GLUD2 complex is a unique synapse organizer that acts bidirectionally on both pre- and postsynaptic components
    INTERACTION
    DNA
    RNA
    small molecule
    protein CBLN1 binds directly to the N-terminal domain of GLUD2 (GLUD2 expression by postsynaptic cells, combined with exogenously applied CBLN1, was necessary and sufficient to induce new synapsesd in the adult cerebellum)
  • interactions between GLUD2 and DLG2 involve more than the extreme terminus of the receptor
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to parkinson disease with earlier onset
    Variant & Polymorphism other a gain-of-function rare polymorphism modifies Parkinson disease onset
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS