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FLASH GENE
Symbol HCFC1 contributors: mct/npt/pgu - updated : 07-03-2017
HGNC name host cell factor C1 (VP16-accessory protein)
HGNC id 4839
DNA
TYPE functioning gene
STRUCTURE 23.81 kb     26 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Binding site   transcription factor
text structure several transcription factor binding sites, six copies of a 17mt long repeat element
MAPPING cloned Y linked N status confirmed
Map cen - L1CAM - AVPR2 - RENBP ,HCFC1 - RGCP@ - G6PD - qter
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
26 - 8436 - 2035 - 2009 19815555
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  moderately
 mouth   moderately
Lymphoid/Immunelymph node   highly
Reproductivefemale systembreastmammary gland highly
 female systemovary  highly
 female systemuteruscervix moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
cell lineage
cell lines
fluid/secretion predominantly in lymph
at STAGE
physiological period embryo
Text
  • highly expressed during embryonic brain development
  • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • octamer sequence (SiSa) known to bind YY1
  • five Kelch repeats, (a Kelch domain at the N terminus of HCF-1N)
  • a fibronectin-like motif
  • six HCF repeats, each of which contains a highly specific cleavage signal
  • conjugated GlycoP
    mono polymer heteromer , dimer
    isoforms Precursor heterodimer of HCF-1N and HCF-1C, which are produced by proteolytic processing of a large precursor protein
    HOMOLOGY
    interspecies homolog to rattus Hcfc1 (94.2 pc)
    homolog to murine Hcfc1 (94.3 pc)
    Homologene
    FAMILY
  • host cell factor family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus,nucleoplasm
    text localized to the Golgi apparatus in unstimulated neurons, a unique location for a transcriptional coactivator
    basic FUNCTION
  • playing a role in the positive regulation of progression through cell cycle
  • involved in the regulation of protein complex assembly
  • induces cell-cycle-specific transcriptional activation by E2F proteins to promote cell proliferation
  • cellular transcriptional coactivator critical for mediating the regulated expression of the immediate-early genes of the herpes simplex virus type 1 and varicella-zoster virus
  • important component of the viral latency-reactivation cycle that is regulated by association with a component that is distinct from the identified HCFC1 interaction factors
  • requirements during M-phase and G0/G1-S phase progression
  • required for stabilizing OGT in the nucleus
  • potent regulator of embryonic neural development
  • unusual transcriptional regulator that undergoes a process of proteolytic maturation to generate N- (HCF-1(N)) and C- (HCF-1(C)) terminal subunits noncovalently associated via self-association sequence elements.
  • functional relationship between HCFC1 and cobalamin metabolism
  • transcriptional co-regulator playing critical roles in promoting cell cycle progression in diverse cell types, and in maintaining self-renewal of embryonic stem cells
  • represents a novel transcriptional regulator required for maintaining pancreatic beta-cell function
  • functions as a direct coregulator of E2F proteins, facilitating the expression of genes necessary for cell proliferation
  • HCFC1 function is required for both extraembryonic and embryonic development
  • roles for HCFC1 in early embryonic cell proliferation and development
  • CELLULAR PROCESS cell cycle, progression
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of a complex with OCT1, POU2F1
  • O-glycosylated
  • heterodimer of HCF-1N and HCF-1C, which are produced by proteolytic processing of a large precursor protein (HCF-1N is essential for G1 phase progression, whereas HCF-1C is important for proper cytokinesis)
  • assembled BAP1/HCFC1/YY1 complex acts to induce the activation of COX7C or other target genes
  • THAP11/ZNF143/HCFC1 complex is a critical component of the transcriptional regulatory network governing cell proliferation
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to YY1 transcription factor
  • binding to herpes simplex virus acidic transactivator protein VP 16
  • binding to the leucine-zipper protein CREB3
  • interacting with E2F1 (E2F1 HCFC1-binding site can modulate both up and down the ability of E2F1 to induce apoptosis indicating that HCFC1 association with E2F1 is a regulator of E2F1-induced apoptosis)
  • binds directly to THAP11 (association with HCFC1 suggests an epigenetic mechanism of gene repression in pluripotent cells)
  • associating with THAP1 and OGT to the RRM1 promoter during endothelial cell proliferation
  • BAP1 is a nuclear deubiquitinase known to target histones (together with ASXL1 as a Polycomb repressor subunit) and the HCFC1 transcriptional co-factor
  • large proportion of the signaling enzyme OGT is complexed with HCFC1 and this interaction is essential for HCFC1 cleavage
  • binding of BAP1 to HCFC1 is likely to be important for BAP1-mediated suppression of RCC development
  • coregulator of the zinc-finger transcription factor THAP11 . directly associates with YY1, and through the interaction of YY1 with MECP2, it regulates mitochondrial adenine nucleotide translocase SLC25A4 and thus might contribute to the pathology of Rett syndrome
  • crucial role of HCFC1 in cell-cycle regulation and particularly in cell growth is supported by its interaction with the deubiquitinating enzyme BAP1
  • KMT2E can associate with the cell cycle regulator "host cell factor" (HCFC1)
  • role for HCFC1 in transcriptional regulation of MMACHC
  • distinct OGT-binding sites in HCFC1 promote proteolysis
  • serves as a scaffold protein, bridging interactions between transcription factors, including THAP11 and ZNF143, and transcriptional coregulators
  • interaction between ZNF143 and HCFC1, a protein that regulates expression of the Cbl trafficking enzyme MMACHC
  • CREB3 interaction with cell cycle regulator HCFC1
  • cell & other
    REGULATION
    Other regulated by BAP1 (BAP1 helps to control cell proliferation by regulating HCFC1 protein levels and by associating with genes involved in the G(1)-S transition)
    protein glycosylation and HCFC1 cleavage occur in the same active site
    ASSOCIATED DISORDERS
    corresponding disease(s) MRX3 , MMACHX
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation     loss of function
    disrupt neuronal and neural progenitor cells of the developing brain
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS