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FLASH GENE
Symbol SMARCA1 contributors: mct - updated : 04-05-2015
HGNC name SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
HGNC id 11097
DNA
TYPE functioning gene
STRUCTURE 76.98 kb     24 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
Binding site   transcription factor
text structure
  • minimal promoter was located between positions &
  • 8722;152 to &
    8722;86 relative to the transcription start site
  • a cAMP-response element (CRE) located at &
  • 8722;99 to &
    8722;92 and a Sp1-binding site at &
    8722;145 to &
    8722;135 that play a critical role in regulating basal activity
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    25 - 4102 - 1054 - 2004 15310751
    - - 4067 - 1054 predominant in non-neuronal tissue 2004 15310751
  • contains a nonconserved in-frame exon within the conserved catalytic core domain of SNF2L
  • retaining the ability to incorporate into multiprotein complexes and however, it is devoid of enzymatic activity
  • catalytically inactive (PMID: 20974961)
  • 24 - 4066 - 1042 - 2004 15310751
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Hearing/Equilibriumear   highly
    Nervousbrain   highly Homo sapiens
    Reproductivefemale systemovary  highly
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • helicase domain, a DNA dependent ATPase/SNF2/DNA helicase activity,
  • a conserved ATPase domain that belongs to the superfamily of DEAD/H-helicases (
  • a bromodomain motif, a SNF2 helicase and two SANT domains at the C terminus
  • HOMOLOGY
    interspecies homolog to Drosophila ISWI (imitation of SWI)
    homolog to yeast S.cerevisiae SWI/SNF general transcriptional activator
    intraspecies paralog to SMARCx
    Homologene
    FAMILY SNF2/Rad54 helicase family
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • actin-dependent regulator of chromatin structure
  • promoting neurite outgrowth and may be playing a role in the differentiation and maturation of neurons during development, and regulating the engrailed homeotic genes, important regulators of brain development
  • involved in multiple nuclear functions, including transcriptional regulation, replication, and chromatin assembly
  • have gene-specific effects on transcription during terminal differentiation
  • physiological target of PARP1 and poly-ADP-ribosylation can be a new, important post-translational modification regulating the activity of ATP-dependent nucleosome remodelers
  • chromatin remodeling gene expressed in diverse tissues, that contributes to the chromatin remodeling complex that facilitates transcription
  • chromatin-remodeling complexes sample nucleosomes via transient binding reactions and become immobilized at active sites
  • evolutionarily conserved nucleosome remodelling factor that regulates gene expression and chromosome organization genome-wide
  • SMARCA1, SMARCA5 are ATP-dependent chromatin remodelling proteins that assemble, reposition and space nucleosomes, and are robustly expressed in the brain
  • SMARCA5 and SMARCA1 position nucleosomes adjacent to CTCF and other transcription factors
  • mobilize nucleosomes to control DNA accessibility and, in some cases, are required for recovery from DNA damage
  • CELLULAR PROCESS nucleotide, chromatin organization, remodeling
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • the chromatin remodeling complexes (NURF complex)
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP
    protein
  • actin
  • associated with the proximal promoter of the steroidogenic acute regulatory protein (STAR) gene, a classic marker of luteinization in granulosa cells, interaction required for STAR expression
  • evolutionary conserved nucleosome-remodeling ATPase interacting with the poly-ADP-ribose polymerase PARP1 (
  • CECR2 is a binding partner of SMARCA1 and is involved in neural tube closure and inner ear development
  • ISWI proteins SMARCA1, SMARCA5 interact with BAZ (bromodomain adjacent to PHD zinc finger) domain containing proteins to generate eight distinct remodeling complexes
  • cell & other matrix associated
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS