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FLASH GENE
Symbol ZNF41 contributors: mct - updated : 09-10-2017
HGNC name zinc finger protein 41
HGNC id 13107
DNA
TYPE functioning gene
STRUCTURE 38.98 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Map see ZNF157
RNA
TRANSCRIPTS type messenger
text several transcripts
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 5359 89 779 - 1999 10449920
5 splicing 5232 89 779 - 1999 10449920
different 5'UTR
4 - 4666 - 693 - 1999 10449920
4 - 4695 - 693 - 1999 10449920
5 - 4956 89 779 - 1999 10449920
5 - 5017 89 779 - 1999 10449920
5 - 5046 - 779 - 1999 10449920
6 - 5144 89 779 - 1999 10449920
6 - 5132 - 693 - 1999 10449920
4 - 4711 - 693 - 1999 10449920
5 - 4972 - 781 - 1999 10449920
5 - 5062 - 781 - 1999 10449920
4 - 4735 - 693 - 1999 10449920
5 - 4996 - 789 - 1999 10449920
5 - 5086 - 789 - 1999 10449920
4 - 5008 - 693 - 1999 10449920
4 - 4907 - 621 - 1999 10449920
4 - 4688 - 745 - 1999 10449920
4 - 4883 - 813 - 1999 10449920
4 - 4673 - 743 - 1999 10449920
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Nervousbrain    
Skeletonaxialskullfacemaxilla 
Visualeyelens   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a KRAB/FBP (Kruppel associated box) at the N terminus
  • a potent transcription repression motif and 18 zinc finger motifs, C2H2 type, Krüppel-like, tandemly arranged at the C terminus
  • conjugated MetalloP
    HOMOLOGY
    Homologene
    FAMILY zinc finger protein family, C2H2 type, Krüppel-like,KRAB subfamily
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in gene-specific transcriptional repression
  • may be playing a critical role for cognitive development
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
    Zn2+
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MRX89
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS