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FLASH GENE
Symbol RBM3 contributors: mct - updated : 28-01-2015
HGNC name RNA binding motif protein 3
HGNC id 9900
DNA
TYPE functioning gene
STRUCTURE 6.81 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
FLJ20573 Xp11.3-p11.1 hypothetical zinc finger protein FLJ20573 SSX6 Xp11.2 synovial sarcoma, X breakpoint 6 psiSSX2 Xp11.2 SSX2 pseudogene LOC389853 X similar to dJ54B20.3 (novel protein similar to lysozyme C (1,4-beta-N-acetylmuramidase)) LOC392460 X similar to Ornithine aminotransferase, mitochondrial precursor (Ornithine--oxo-acid aminotransferase) psiSSX3 Xp11.2 SSX3 pseudogene SSX5 Xp11.2-p11.1 synovial sarcoma, X breakpoint 5 LOC392462 X similar to synovial sarcoma, X breakpoint 6 SSX1 Xp11.23-p11.22 synovial sarcoma, X breakpoint 1 psiSSX8 Xp11.2 psiSSX8 pseudogene SSX9 Xp11.23 synovial sarcoma, X breakpoint 9 psiSSX9 Xp11.2 SSX9 pseudogene SSX3 Xp11.2-p11.1 synovial sarcoma, X breakpoint 3 SSX4 Xp11.2-p11.1 synovial sarcoma, X breakpoint 4 SLC38A5 Xp11.23 solute carrier family 38, member 5 FTSJ1 Xp11.23 FtsJ homolog 1 (E. coli) PPN Xp11.23 likely ortholog of mouse porcupine homolog (Drosophila) EBP Xp11.23-p11.22 emopamil binding protein (sterol isomerase) OATL1 Xp11.23-p11.22 ornithine aminotransferase-like 1 RBM3 Xp11.23 RNA binding motif protein 3 MRPL32P1 Xq11.23 RNA binding motif protein 3 WDR13 Xp11.23 WD repeat domain 13 WAS Xp11.23-p11.22 Wiskott-Aldrich syndrome (eczema-thrombocytopenia) SUV39H1 Xp11.23 suppressor of variegation 3-9 homolog 1 (Drosophila) LOC392465 X similar to RIKEN cDNA 2010001H14 LOC389854 X similar to Acetyl-coenzyme A acyltransferase 2 GATA1 Xp11.23 GATA binding protein 1 (globin transcription factor 1) HDAC6 Xp11.23 histone deacetylase 6 ERAS Xpter-q26 ES cell expressed Ras PCSK1N Xp11.23 proprotein convertase subtilisin/kexin type 1 inhibitor TIMM17B Xp11.23 translocase of inner mitochondrial membrane 17 homolog B (yeast) PQBP1 Xp11.3 polyglutamine binding protein 1 SLC35A2 Xp11.23-p11.22 solute carrier family 35 (UDP-galactose transporter), member A2 PIM2 Xp11.3-p11.2 pim-2 oncogene DKFZp761A052 Xp11.23 hypothetical protein DKFZp761A052
regionally located located between OATL1 and GATA1/TFE3 in subband Xp11.23
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 4432 - 157 - -
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
 liver   highly
Lymphoid/Immunespleen   highly
Reproductivemale systemtestis  highlyMus musculus
cells
SystemCellPubmedSpeciesStageRna symbol
ReproductiveSertoli cell Mus musculus
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal RNP (RRM) motif
  • one serine/arginine-glycine (SRGY) box in the C terminal region
  • HOMOLOGY
    interspecies ortholog to murine Rbm3
    homolog to C.elegans T12D8.2
    intraspecies homolog to RBM1,RBM2 (see symbols)
    homolog to YRRM (RBMY1A1)
    homolog to HNRPG
    Homologene
    FAMILY glycine-rich RNA-binding protein family
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • playing a formerly unknown role in the regulation of programmed cell death (apoptosis) in breast cancer
  • RNA stabilizing and translation regulatory protein RBM3 is a novel proto-oncogene that induces transformation when overexpressed and is essential for cells to progress through mitosis
  • is a critical factor providing cellular survival advantages in an adverse microenvironment presumably by restoring translation efficacy
  • is involved in hypothermia induced neuroprotection
  • RBM3 and CIRBP are two established cold-shock proteins
  • may have proliferative and/or proto-oncogenic functions in human astrocytomas
  • CIRBP and RBM3, are important regulators for the temperature entrained circadian gene expression
  • RBM3 has potentially a dual function: one as a chaperone protein that stabilizes mRNA transcripts and a second one in enhancing the transcription of ALPP and BGLAP genes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • CIRBP and RBM3 regulated the circadian gene expression by controlling alternative polyadenylation (APA)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    associated with clinically more aggressive tumours and an independent factor of poor prognosis in patients with urothelial bladder cancer
    tumoral     --over  
    of RBM3 is an independent predictor of good prognosis in colorectal cancer
    constitutional     --over  
    decreases muscle cell necrosis as well as apoptosis and therefore RBM3 could potentially serve as an intervention for the loss of muscle cell viability during muscle atrophy and muscle diseases
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Rbm3(-/-) mouse embryonic fibroblasts (MEFs) showed poorer proliferation rates as compared to control MEFs, and have markedly increased number of G2-phase cells, suggesting a hitherto unknown role of RBM3 in the G2-phase control