basic FUNCTION
| classical pathway of C3 activation |
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possessing a proteinase activity to C1S |
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is a modular serine protease which is the autoactivating component of the C1 complex of the classical pathway of the complement system |
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modular C1R protein is the first protease activated in the classical complement pathway, a key component of innate immunity |
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serine protease, that initiates activation of the classical pathway of complement, which is a crucial innate defense mechanism against pathogens and altered-self cells |
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C1R specificity is well suited to its cleavage targets and efficient cleavage of C1S is achieved through both active site and exosite contributions |
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C1QA binds to the nucleolus in advanced apoptotic cells, and the C1QA-associated C1R/C1S proteases degrade nucleolar proteins |