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FLASH GENE
Symbol STS contributors: mct/npt - updated : 27-01-2010
HGNC name steroid sulfatase (microsomal), isozyme S
HGNC id 11425
DNA
TYPE functioning gene
SPECIAL FEATURE
text
  • X-linked, escaping inactivation
  • flanked in both sides by a repetitive sequence CRI-S232 which includes a VCX sequence
  • STRUCTURE 135.21 kb     10 Exon(s)    1 Copie(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    Map see CDPX1 , PRPS2 , KAL1 KAL1
    RNA
    TRANSCRIPTS type messenger
    text STS expression, in different human tissues, could be regulated by at least six different promoters associated with alternative first exon (Nardi 2009)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 6377 - 583 - Valle (2007)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland    
    Reproductivefemale systemplacenta  highly
     female systemovary   
     male systemtestis   
    Respiratoryrespiratory tractlarynx  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • trypsin domain
  • mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • sulfatase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic,microsome
    intracellular,nuclear envelope
    text membrane-bound microsomal (Valle 2007)
    basic FUNCTION
  • desulphating a number of 3beta-hydroxysteroid sulphates
  • catalyzing the conversion of sulfated steroid precursors to estrogens during pregnancy
  • playing a crucial role in the intra-mitochondrial movement of cholesterol
  • may play a role in susceptibility for attention deficit hyperactivity disorder (Brookes 2008)
  • membrane-bound microsomal enzyme that hydrolyzes various alkyl and aryl steroid sulfates (Nardi 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • binds 1 calcium ion per subunit
  • protein
  • increasing STAR protein expression level and stimulating steroid production
  • cell & other
    REGULATION
    activated by thyroid hormones
    ASSOCIATED DISORDERS
    corresponding disease(s) SSDI , DELXPM
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in endometrial carcinomas
    Susceptibility to attention deficit hyperactivity disorder (Brookes 2008)
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS