basic FUNCTION
| cell surface glycoprotein whose engagement has been implicated in cell proliferation as well as upregulation and transport of several transmembrane proteins in hematopoietic cells |
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cell surface glycoprotein whose engagement has been implicated in cell proliferation as well as upregulation and transport of several transmembrane proteins in hematopoietic cells |
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involved in T cell adhesion processes |
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involved in crucial processes of cancer malignancy, serving as a curtain raiser for this, so far neglected molecule |
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plays a pivotal role in the reversion of the malignant phenotype |
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acting as a potent suppressor of malignancy in osteosarcoma |
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is essential for leukocyte diapedesis |
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CD99 and CD99L2 act independently of PECAM1 in leukocyte extravasation and cooperate in an independent way to help neutrophils overcome the endothelial basement membrane |
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PECAM1 and CD99 are involved in the reverse transmigration (RT) of tissue-resident dendritic cells (DCs) across lymphatic endothelial cells (LECs) and similar mechanisms promote both diapedesis and RT |
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SEPTIN2-mediated cytoskeletal rearrangement and STMN1-mediated differentiation may contribute to changes in cell morphology and differentiation of Hodgkin and Reed-Sternberg (H/RS) cells with CD99 upregulation in Hodgkin lymphoma (HL) |
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endothelial CD99 signals through soluble adenylyl cyclase and PRKAA to regulate leukocyte transendothelial migration |
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CD99 and SLC3A2 oppositely regulate ITGB1 signaling |
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CD99-induced dephosphorylation of PTK2 was apparently mediated by the recruitment of PTPN11 to the plasma membrane and subsequent activation of its phosphatase activity |
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important role for CD99 in the pathogenesis of CNS autoimmunity |