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FLASH GENE
Symbol MCF2 contributors: - updated : 31-12-2004
HGNC name MCF.2 cell line derived transforming sequence
HGNC id 6940
DNA
TYPE functioning gene
STRUCTURE 60.00 kb     26 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Physical map
RBMX Xq26 RNA binding motif protein, X chromosome LOC389890 X hypothetical gene supported by AF419855; NM_005839 LOC389891 X similar to ENSANGP00000013187 GPR101 Xq25-27.1 G protein-coupled receptor 101 LOC286472 Xq26.3 similar to Ras-related C3 botulinum toxin substrate homolog DJ20J23.1 ZIC3 Xq26.2 Zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila) LOC389892 X similar to Mothers against decapentaplegic homolog interacting protein (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP) LOC139363 Xq27.1 similar to melanoma antigen, family A, 10; melanoma-associated antigen 10; MAGE-10 antigen LOC392552 X similar to cytokeratin 8 FLJ30672 Xq27.1 hypothetical protein FLJ30672 FGF13 Xq26 fibroblast growth factor 13 SRD5AP1 Xq24-qter steroid-5-alpha-reductase, alpha polypeptide pseudogene 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha pseudogene) F9 Xq26.3-q27.1 coagulation factor IX (plasma thromboplastic component, Christmas disease, hemophilia B) MCF2 Xq26.3-q27.1 MCF.2 cell line derived transforming sequence BCYRN1P1  brain cytoplasmic RNA 1, pseudogene 1 ATP11C X ATPase, Class VI, type 11C LOC347487 Xq27.1 hypothetical LOC347487 LOC389893 X LOC389893 LOC389894 X hypothetical gene supported by NM_194247 LOC389895 X similar to PRO0149 protein LOC389896 X LOC389896 LOC266694 Xq27.1 embryonic ectoderm development pseudogene SOX3 Xq27.1 SRY (sex determining region Y)-box 3 CDR1 Xq27.1-q27.2 cerebellar degeneration-related protein 1, 34kDa SPANXB1 Xq27.1 SPANX family, member B1 dJ507I15.1 Xq27.1 ribosomal protein L36a pseudogene LDOC1 Xq27.2 leucine zipper, down-regulated in cancer 1 SPANXC Xq27.1 SPANX family, member C NDUFB3P5  NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa pseudogene 5 SPANXA1 Xq27.1 sperm protein associated with the nucleus, X chromosome, family member A1 LOC389897 X hypothetical gene supported by BC042039 SPANXE Xq27.1 SPANX family, member E SPANXD Xq27.1 SPANX family, member D MAGEC3 Xq27.2 melanoma antigen, family C, 3 MAGEC1 Xq26 melanoma antigen, family C, 1 LOC392554 X similar to melanoma antigen, family A, 10; melanoma-associated antigen 10; MAGE-10 antigen
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   highly
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivegerm cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES Hydrophilic
STRUCTURE
motifs/domains
  • a pleckstrin homology (PH)
  • a DBL domains and a SH3 domain
  • a RhoGEF domain
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to yeast Cdc24
    intraspecies homolog to Ascidian protein posterior End MARK2 (PEM2)
    Homologene
    FAMILY
    CATEGORY regulatory , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • GDP-GTP exchange factor for CDC42HS, specifically activating CDC42 and not RAC or RHOA
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS