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FLASH GENE
Symbol ALAD contributors: npt/ - updated : 13-11-2006
HGNC name aminolevulinate, delta-, dehydratase
HGNC id 395
DNA
TYPE functioning gene
STRUCTURE 15.03 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 3317 - 330 - -
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveliver   highly
 mouthtongue  moderately
 stomach   moderately
Lymphoid/Immunespleen   highly
Nervousbrain   moderately
Reproductivefemale systemplacenta  moderately
 female systembreastmammary gland moderately
 male systemprostate   
Urinarybladder   moderately
 kidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticerythroblast
cell lineage
cell lines
fluid/secretion blood
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a catalytic domain
  • secondary structure an alpha 1 helix at the N terminus
    mono polymer homomer , dimer , hexamer
    HOMOLOGY
    interspecies ortholog to murine Alad
    ortholog to rattus Alad
    Homologene
    FAMILY
  • ALADH family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • catalyzing the condensation of two molecules of delta-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins)
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism porphyrin/heme
    signaling
    second step of porphyrin and heme biosynthesis
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor,
  • Zn2+
  • protein
    cell & other
    REGULATION
    inhibited by lead
    ASSOCIATED DISORDERS
    corresponding disease(s) ALADD
    Susceptibility to lead poisoning
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS