Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CYP3A7 contributors: mct - updated : 05-04-2019
HGNC name cytochrome P450, family 3, subfamily A, polypeptide 7
HGNC id 2640
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
text cluster of cytochrome P450 genes
STRUCTURE 30.00 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing - - - in liver, kidney, gastrointestinal tract Rodriguez-Antona
  • 15 exons
  • the last four carboxyl-terminal amino acids replaced by a unique sequence of 36 amino acids
  • could play an important role with developmental, physiological and toxicological processes
  • - - 2080 - 503 - Thompson
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Cardiovascularheart    
    Digestiveliver   predominantly Homo sapiensFetal
     liver   predominantly Homo sapiensAdult
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, fetal, pregnancy
    Text highly in liver, heart, pregnant uterus
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated HemoP
    mono polymer monomer
    HOMOLOGY
    Homologene
    FAMILY
  • cytochrome P450 subfamily IIIA
  • multigenic cytochrome P450 superfamily of mixed-function monooxygenases
  • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • niphedipine oxidase involved in drug metabolism and synthesis of cholesterol, steroids and other lipids
  • hydroxylation of testosterone and dehydroepiandrosterone 3-sulfate
  • plays a potential role in modulation of dehydroepiandrosterone and its sulfate levels
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism drug , hormone
    signaling
    estriol formation during pregnancy
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
    NADPH, heme
    protein flavoprotein P450 oxidoreductase (POR)
    cell & other
    REGULATION
    Other regulated by Sp1,Sp3,HNF3B,USF1
    ASSOCIATED DISORDERS
    corresponding disease(s)
    related resource Human Cytochrome P450 (CYP) Allele Nomenclature Committee
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS